Gaynor Louise M, Colucci Francesco
Centre for Trophoblast Research, University of Cambridge, Cambridge, UK.
Department of Obstetrics and Gynaecology, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Front Immunol. 2017 Apr 24;8:467. doi: 10.3389/fimmu.2017.00467. eCollection 2017.
Our understanding of development and function of natural killer (NK) cells has progressed significantly in recent years. However, exactly how uterine NK (uNK) cells develop and function is still unclear. To help investigators that are beginning to study tissue NK cells, we summarize in this review our current knowledge of the development and function of uNK cells, and what is yet to be elucidated. We compare and contrast the biology of human and mouse uNK cells in the broader context of the biology of innate lymphoid cells and with reference to peripheral NK cells. We also review how uNK cells may regulate trophoblast invasion and uterine spiral arterial remodeling in human and murine pregnancy.
近年来，我们对自然杀伤（NK）细胞的发育和功能的理解有了显著进展。然而，子宫NK（uNK）细胞究竟如何发育和发挥功能仍不清楚。为了帮助刚开始研究组织NK细胞的研究人员，我们在这篇综述中总结了我们目前对uNK细胞发育和功能的认识，以及尚待阐明的问题。我们在固有淋巴细胞生物学的更广泛背景下，并参照外周NK细胞，比较和对比了人类和小鼠uNK细胞的生物学特性。我们还综述了uNK细胞在人类和小鼠妊娠中如何调节滋养层细胞浸润和子宫螺旋动脉重塑。
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