Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, New York, USA.
Nat Immunol. 2016 Jun 21;17(7):765-74. doi: 10.1038/ni.3489.
Research over the last 7 years has led to the formal identification of innate lymphoid cells (ILCs), increased the understanding of their tissue distribution and has established essential functions of ILCs in diverse physiological processes. These include resistance to pathogens, the regulation of autoimmune inflammation, tissue remodeling, cancer and metabolic homeostasis. Notably, many ILC functions appear to be regulated by mechanisms distinct from those of other innate and adaptive immune cells. In this Review, we focus on how group 2 ILC (ILC2) and group 3 ILC (ILC3) responses are regulated and how these cells interact with other immune and non-immune cells to mediate their functions. We highlight experimental evidence from mouse models and patient-based studies that have elucidated the effects of ILCs on the maintenance of tissue homeostasis and the consequences for health and disease.
在过去的 7 年中，研究已经导致了先天淋巴细胞（ILC）的正式鉴定，增加了对其组织分布的理解，并确立了 ILC 在多种生理过程中的基本功能。这些功能包括抵抗病原体、调节自身免疫炎症、组织重塑、癌症和代谢稳态。值得注意的是，许多 ILC 功能似乎受到不同于其他先天和适应性免疫细胞的机制的调节。在这篇综述中，我们重点讨论了 2 型 ILC（ILC2）和 3 型 ILC（ILC3）反应是如何受到调节的，以及这些细胞如何与其他免疫和非免疫细胞相互作用来介导它们的功能。我们强调了来自小鼠模型和基于患者的研究的实验证据，这些证据阐明了 ILC 对维持组织稳态的影响，以及对健康和疾病的后果。
