Zhang Z-G, Chen F, Ou Y
Department of Pharmacy, Liaocheng People's Hospital, Liaocheng, Shandong, China.
Department of Pharmacy, Shandong University Qilu Hospital, Jinan, China.
J Clin Pharm Ther. 2017 Oct;42(5):579-584. doi: 10.1111/jcpt.12544. Epub 2017 May 8.
Antimicrobial misuse has been commonly observed in China. This phenomenon can cause antibiotic resistance. This study was designed to evaluate the impact of an antimicrobial stewardship programme implemented in a tertiary hospital in China from 2011 to 2014.
The antimicrobial stewardship programme began in 2011. Data on the consumption of antibiotics and antimicrobial resistance between 2011 and 2014 were collected.
Comparison of the 2011 data with those of 2014 showed that antibiotic defined daily doses/per 100 patient-days decreased from 92.5±2.8 to 35.8±1.2 (P<.01). The detection rate of the extended-spectrum β-lactamase content of Escherichia coli (E. coli) and Klebsiella pneumoniae strains in 2014 was reduced. The resistance of E. coli and K. pneumonia to amikacin, gentamicin and ceftriaxone was significantly reduced (P<.01).
Our study reports positive responses to antimicrobial control measures in a Chinese tertiary hospital. It elucidates that the antimicrobial programme including administrative management, especially information management, was effective in reducing antibiotic consumption and lessening antibiotic resistance.
在中国，抗菌药物滥用现象普遍存在。这种现象会导致抗生素耐药性。本研究旨在评估2011年至2014年在中国一家三级医院实施的抗菌药物管理计划的影响。
抗菌药物管理计划于2011年启动。收集了2011年至2014年期间抗生素消费和抗菌药物耐药性的数据。
将2011年的数据与2014年的数据进行比较，结果显示抗生素限定日剂量/每100患者日从92.5±2.8降至35.8±1.2（P<0.01）。2014年大肠杆菌（E. coli）和肺炎克雷伯菌菌株的超广谱β-内酰胺酶含量检测率降低。大肠杆菌和肺炎克雷伯菌对阿米卡星、庆大霉素和头孢曲松的耐药性显著降低（P<0.01）。
我们的研究报告了中国一家三级医院对抗菌药物控制措施的积极反应。阐明了包括行政管理，尤其是信息管理在内的抗菌药物管理计划在减少抗生素消费和降低抗生素耐药性方面是有效的。
