Institute of Pharmacy, Shandong Provincial Third Hospital, Jinan 250031, Shandong, China.
Eur J Hosp Pharm. 2020 Sep;27(5):286-291. doi: 10.1136/ejhpharm-2018-001609. Epub 2019 Jan 19.
The scientific antimicrobial management strategy (AMS) was used to standardise the clinical use of antibiotics and optimise the anti-infection treatment protocol.
By formulating antibiotic use indicators and policy interventions, carrying out prescription audits and drug analysis by pharmacists, and establishing an early warning mechanism for bacterial drug resistance, we formed a long-term and scientific antimicrobial management strategy.
From 2012 to 2017, the clinical antibiotics use indicators appeared to trend downward. The rate of antibiotic use in outpatients, the rate of antibiotic use in hospitalised patients, and the antimicrobial use density decreased by 40.36%, 20.93%, and 10.71%, respectively, and the per capita drug cost of antibiotics in outpatients and inpatients decreased. The microbiological susceptibility test rate of antibiotics in hospitalised patients increased each year, and the resistance rate of the main detected bacteria did not significantly increase in the last 6 years. In the evaluation of rational drug use, the use of antibiotics has become more reasonable and standardised, and irrational drug use has been significantly reduced, but we still need to strengthen the optimisation of treatment prescription.
Scientific management can promote the rational use of antibiotics, reduce the expense of drug use and slow the development of drug resistance, but we need to further optimise the prescription of antibiotics to improve the level of drug treatment.
采用科学的抗菌药物管理策略（AMS）规范抗菌药物临床应用，优化抗感染治疗方案。
通过制定抗菌药物使用指标和政策干预措施，开展处方审核和药师药物利用分析，建立细菌耐药预警机制，形成长期科学的抗菌药物管理策略。
2012 年至 2017 年，临床抗菌药物使用指标呈下降趋势，门诊抗菌药物使用率、住院患者抗菌药物使用率和抗菌药物使用强度分别下降了 40.36%、20.93%和 10.71%，门诊和住院患者抗菌药物人均药品费用下降。住院患者抗菌药物微生物送检率逐年上升，主要检测细菌耐药率在近 6 年内无明显上升。在合理用药评价中，抗菌药物使用更加合理规范，不合理用药明显减少，但仍需加强治疗方案的优化。
科学管理可促进抗菌药物合理应用，降低用药费用，延缓耐药发展，但仍需进一步优化抗菌药物处方，提高药物治疗水平。
