Sharma D, Singh G
Department of Radiotherapy, VMMC and Safdarjung Hospital, New Delhi, India.
Indian J Cancer. 2016 Oct-Dec;53(4):566-568. doi: 10.4103/ijc.IJC_534_16.
Most common breast cancer in India among female is breast cancer. This is heterogeneous disease, one of the subtypes, triple negative breast cancer (TNBC) defined as no expression of estrogen, progesterone receptor and neither expression nor amplification of human epidermal growth factor receptor 2/neu. TNBC is more frequent and aggressive in younger age group. The aim of this study was to evaluate clinicopathological features and outcome in TNBC versus non-TNBC group of patients.
Medical record of 373 patients diagnosed with invasive breast cancer from January 2011 to December 2014 was retrieved. The last follow-up was done in December 2015. Patients were evaluated and grouped on the basis of receptor status (TNBC vs. non-TNBC). Baseline categorical variables were analyzed using the Chi-square test or Fisher's exact test. Noncategorical variables were analyzed using t-test.
Out of 373 cases, 149 (39.94%) were diagnosed as TNBC. Patients with TNBC had a significantly lower median age (45 vs. 48 years). Data analysis revealed significant difference in number of metastasis in TNBC as compared to non-TNBC group (45.6% vs. 25.6%, P = 0.001). In the present study, mean disease-free survival was 14.73 versus 17.03 months (P = 0.22, not significant) and mean overall survival was 24.71 versus 27.38 months (P = 05, significant) in TNBC versus non-TNBC group, respectively.
TNBC represented 39.94% which is higher than the range normally reported in literature. TNBC is associated with younger age, high-grade tumors, and a higher rate of distant metastasis.
在印度女性中，最常见的乳腺癌类型就是乳腺癌。这是一种异质性疾病，其中一个亚型为三阴性乳腺癌（TNBC），其定义为雌激素、孕激素受体均无表达，且人表皮生长因子受体2/neu既无表达也无扩增。TNBC在较年轻年龄组中更为常见且侵袭性更强。本研究的目的是评估TNBC组与非TNBC组患者的临床病理特征及预后。
检索了2011年1月至2014年12月期间诊断为浸润性乳腺癌的373例患者的病历。最后一次随访于2015年12月进行。根据受体状态（TNBC与非TNBC）对患者进行评估和分组。使用卡方检验或Fisher精确检验分析基线分类变量。使用t检验分析非分类变量。
在373例病例中，149例（39.94%）被诊断为TNBC。TNBC患者的中位年龄显著更低（45岁对48岁）。数据分析显示，与非TNBC组相比，TNBC的转移数量存在显著差异（45.6%对25.6%，P = 0.001）。在本研究中，TNBC组与非TNBC组的平均无病生存期分别为14.73个月对17.03个月（P = 0.22，无显著差异），平均总生存期分别为24.71个月对27.38个月（P = 0.05，有显著差异）。
TNBC占39.94%，高于文献中通常报道的范围。TNBC与较年轻的年龄、高级别肿瘤以及更高的远处转移率相关。
