Duchemin Nicolas, Heath-Apostolopoulos Isabelle, Smietana Michael, Arseniyadis Stellios
Queen Mary University of London, School of Biological and Chemical Sciences, Mile End Road, London, E1 4NS, UK.
Org Biomol Chem. 2017 Aug 30;15(34):7072-7087. doi: 10.1039/c7ob00176b.
In a little over a decade, the unique chirality of oligonucleotides has allowed the development of a variety of asymmetric synthetic transformations. The concept lies in embedding an achiral transition metal catalyst in a DNA double helix, which provides the necessary chiral microenvironment to selectively form one enantiomer of a given reaction product. The most recent efforts at unveiling new reactivities have been accompanied by the desire to understand the mechanisms by which the chirality is transferred and the influence of the interaction between DNA and the metallic co-factor on the selectivity. By offering a complete overview of the field, this review aims to highlight the intricate correlation between the structure of the chiral bio-inorganic scaffold and its catalytic efficacy.
在短短十多年的时间里,寡核苷酸独特的手性使得各种不对称合成转化得以发展。其理念是将非手性过渡金属催化剂嵌入DNA双螺旋结构中,该结构提供必要的手性微环境,以选择性地形成给定反应产物的一种对映体。在揭示新反应活性的最新研究中,人们渴望了解手性转移的机制以及DNA与金属辅因子之间的相互作用对选择性的影响。通过全面概述该领域,本综述旨在突出手性生物无机支架结构与其催化效能之间的复杂关联。