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从DNA模板超分子自组装中的相互作用到功能

From Interaction to Function in DNA-Templated Supramolecular Self-Assemblies.

作者信息

Surin Mathieu, Ulrich Sébastien

机构信息

Laboratory for Chemistry of Novel Materials Center of Innovation and Research in Materials and Polymers (CIRMAP) University of Mons-UMONS 7000 Mons Belgium.

IBMM Université de Montpellier, CNRS, ENSCM Montpellier France.

出版信息

ChemistryOpen. 2020 Apr 22;9(4):480-498. doi: 10.1002/open.202000013. eCollection 2020 Apr.

DOI:10.1002/open.202000013
PMID:32328404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7175023/
Abstract

DNA-templated self-assembly represents a rich and growing subset of supramolecular chemistry where functional self-assemblies are programmed in a versatile manner using nucleic acids as readily-available and readily-tunable templates. In this review, we summarize the different DNA recognition modes and the basic supramolecular interactions at play in this context. We discuss the recent results that report the DNA-templated self-assembly of small molecules into complex yet precise nanoarrays, going from 1D to 3D architectures. Finally, we show their emerging functions as photonic/electronic nanowires, sensors, gene delivery vectors, and supramolecular catalysts, and their growing applications in a wide range of area from materials to biological sciences.

摘要

DNA模板自组装是超分子化学中一个丰富且不断发展的分支领域，其中利用核酸作为易于获取且易于调节的模板，以多种方式对功能性自组装体进行编程。在本综述中，我们总结了不同的DNA识别模式以及在此背景下发挥作用的基本超分子相互作用。我们讨论了最近的研究成果，这些成果报道了小分子通过DNA模板自组装形成复杂而精确的纳米阵列，从一维结构到三维结构。最后，我们展示了它们作为光子/电子纳米线、传感器、基因传递载体和超分子催化剂的新兴功能，以及它们在从材料科学到生物科学等广泛领域中不断增加的应用。

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