Bäckryd Emmanuel, Heilig Markus, Hoffmann Mikael
Pain and Rehabilitation Centre - Department of Medical and Health Sciences Linköping, Sweden Pain and Rehabilitation Centre - Department of Medical and Health Sciences Linköping, Sweden.
Linkopings Universitet Institutionen for klinisk och experimentell medicin - Linkoping, Sweden.
Lakartidningen. 2017 May 2;114:EFUE.
Opioid prescription changes in Sweden 2000-2015 In contrast to the well-established »opioid epidemic« in the US, very little is known about how the prescription of opioids in Sweden has developed during the last decade. Aggregated data from the open Statistical database of the Swedish Board of Health and Welfare were analyzed descriptively. The yearly prevalence of opioid prescription did not change 2006-2015, but there were dramatic shifts in the choice of opioids. During this period, dextropropoxyphene was pulled off the market. Tramadol was used by fewer individuals (-54 % over the decade), but dosages expressed as Defined Daily Dose/patient/year (DDD/pat/y) increased (+41 %). In contrast, oxycodone and morphine were used by more individuals (+465 % and +137 %, respectively), but DDD/pat/y decreased during the period (-56% and -54%). Studies on non-aggregated data from available registries are needed to further elucidate the circumstances and possible consequences of these shifts in opioid prescription patterns.
2000 - 2015年瑞典的阿片类药物处方变化 与美国已广为人知的“阿片类药物流行”情况不同，对于瑞典阿片类药物处方在过去十年间是如何发展的，人们知之甚少。对瑞典卫生和福利委员会开放统计数据库中的汇总数据进行了描述性分析。2006 - 2015年阿片类药物处方的年患病率没有变化，但阿片类药物的选择发生了显著变化。在此期间，右丙氧芬退出市场。使用曲马多的人数减少（十年间减少了54%），但以限定日剂量/患者/年（DDD/患者/年）表示的剂量增加（增加了41%）。相比之下，使用羟考酮和吗啡的人数增加（分别增加了465%和137%），但在此期间DDD/患者/年减少（分别减少了56%和54%）。需要对来自现有登记处的非汇总数据进行研究，以进一步阐明这些阿片类药物处方模式变化的情况及其可能产生的后果。
