Almér Herrnsdorf Eleonora, Holmstedt Alexander, Håkansson Anders
Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Psychiatry, Lund, Sweden.
Malmö Addiction Center, Region Skåne, Malmö, Sweden.
Addict Behav Rep. 2022 Jul 11;16:100446. doi: 10.1016/j.abrep.2022.100446. eCollection 2022 Dec.
Non-medical prescription use of opioids (NMPUO) is a public health concern worldwide. Recently, tramadol misuse is increasing, but the systematic research of misuse of this specific opioid is limited. This study set out to assess the relationship between tramadol use and completion of treatment for substance use among adolescents and adults ≤ 25 years in an outpatient clinical setting. A retrospective cohort study of treatment outcome, expressed as "completion" or "non-completion" of treatment, was conducted in treatment-seeking adolescents with problematic substance use (n = 335). Data was extracted from Ung-DOK interviews, a semi-structured assessment instrument designed for adolescents with substance abuse. The study included all treatment-seeking patients at an out-patient facility in 2014-2017. A total of 26% (n = 88) were tramadol users (life-time prevalence). Twenty percent (n = 66) of all treatments were non-completed. Tramadol users were significantly more likely than non-users to drop out of treatment (35% vs 15%, p < 0.001). In multivariate logistic regression, tramadol use and age 18 and above were factors significantly associated with non-completion. Tramadol use was statistically significantly associated with non-completion of treatment. Further research addressing treatment needs and treatment completion among tramadol users is needed.
阿片类药物的非医疗处方使用（NMPUO）是一个全球性的公共卫生问题。最近，曲马多滥用情况不断增加，但针对这种特定阿片类药物滥用的系统性研究有限。本研究旨在评估门诊临床环境中，青少年及25岁及以下成年人使用曲马多与物质使用治疗完成情况之间的关系。对有物质使用问题的青少年（n = 335）进行了一项回顾性队列研究，治疗结果以治疗“完成”或“未完成”来表示。数据从Ung-DOK访谈中提取，这是一种为有药物滥用问题的青少年设计的半结构化评估工具。该研究纳入了2014 - 2017年门诊机构中所有寻求治疗的患者。共有26%（n = 88）为曲马多使用者（终生患病率）。所有治疗中有20%（n = 66）未完成。曲马多使用者比非使用者更有可能退出治疗（35%对15%，p < 0.001）。在多因素逻辑回归中，使用曲马多及18岁及以上是与治疗未完成显著相关的因素。使用曲马多与治疗未完成在统计学上显著相关。需要进一步研究解决曲马多使用者的治疗需求和治疗完成情况。
