桩蛋白的结构和功能及其在血管新生中的作用。

The structure and functions of paxillin and its roles in neovascularization.

机构信息

Department of Ophthalmology, Key Laboratory for Molecular Diagnosis of Hubei Province, the Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.

出版信息

Eur Rev Med Pharmacol Sci. 2017 Apr;21(8):1768-1773.

PMID:28485804

Abstract

Identifying and studying the molecular mechanisms of neovascularization biomarkers are critical for conquering many diseases, such as corneal diseases and cancer. Paxillin is an important cell scaffold and cellular signaling protein, especially a key molecule of the Integrin-mediated downstream signaling transduction. This review summarizes the structure and functions of paxillin, and the research progress of its roles in neovascularization. Although there are still some problems to be solved, paxillin may become an important target of anti-neovascularization therapies.

摘要

鉴定和研究新生血管生物标志物的分子机制对于攻克许多疾病（如角膜疾病和癌症）至关重要。桩蛋白（Paxillin）是一种重要的细胞支架和细胞信号蛋白，特别是整合素介导的下游信号转导的关键分子。本文综述了桩蛋白的结构和功能，以及其在新生血管形成中的作用的研究进展。尽管仍存在一些需要解决的问题，但桩蛋白可能成为抗新生血管形成治疗的重要靶点。