Vadivelu Malarvizhi, Rathore Swati, Benjamin Santosh J, Abraham Anuja, Belavendra Antonisamy, Mathews Jiji E
Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamilnadu, India.
Department of Biostatistics, Christian Medical College, Vellore, Tamilnadu, India.
Int J Gynaecol Obstet. 2017 Aug;138(2):152-157. doi: 10.1002/ijgo.12203. Epub 2017 Jun 2.
To investigate the effect of amniotomy on the duration of spontaneous labor.
In the present randomized controlled trial, women in spontaneous labor with singleton pregnancies presenting at a tertiary teaching hospital in South India between August 1, 2014, and October 31, 2015, were randomized in a 1:1 ratio to undergo amniotomy or conservative management. The primary outcome was the duration of labor. Per-protocol analyses were performed and the duration of labor was compared between the groups of patients.
There were 144 patients randomized to each group. The median duration of labor was 235 minutes (interquartile range 117-355) in the amniotomy group and 364 minutes (interquartile range 201-580) in the conservative management group (P<0.001).
Amniotomy was associated with a shorter duration of labor in comparison with conservative management in patients with singleton pregnancies experiencing spontaneous labor. Clinical Trials Registry-India: (CTRI) (CTRI/2014/12/005264).
探讨人工破膜对自然分娩产程的影响。
在本随机对照试验中，2014年8月1日至2015年10月31日期间，在印度南部一家三级教学医院就诊的单胎妊娠自然分娩妇女按1:1比例随机分组，分别接受人工破膜或保守治疗。主要结局指标为产程。进行符合方案分析，并比较两组患者的产程。
每组随机分配144例患者。人工破膜组的中位产程为235分钟（四分位间距117 - 355），保守治疗组为364分钟（四分位间距201 - 580）（P<0.001）。
与单胎妊娠自然分娩患者的保守治疗相比，人工破膜与较短的产程相关。印度临床试验注册中心：（CTRI）（CTRI/2014/12/005264）
