Azzolin Luca, Piccolo Stefano
Department of Molecular Medicine, University of Padua School of Medicine, viale Colombo 3, 35126 Padua, Italy.
Department of Molecular Medicine, University of Padua School of Medicine, viale Colombo 3, 35126 Padua, Italy.
Cancer Cell. 2017 May 8;31(5):607-608. doi: 10.1016/j.ccell.2017.04.009.
In this issue of Cancer Cell, Diamantopoulou et al. uncover dual mechanisms of inhibiting YAP/TAZ by TIAM1 that oppose invasiveness of colorectal cancer cells: TIAM1 interacts with TAZ in the cytoplasm to promote TAZ degradation by the destruction complex, whereas it antagonizes binding of TAZ/YAP to TEAD in the nucleus.
在本期《癌细胞》杂志中，迪亚曼托普洛等人发现了TIAM1抑制YAP/TAZ的双重机制，这两种机制可对抗结肠癌细胞的侵袭性：TIAM1在细胞质中与TAZ相互作用，通过破坏复合体促进TAZ降解，而在细胞核中它则拮抗TAZ/YAP与TEAD的结合。
