Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cancer Cell. 2017 May 8;31(5):609-611. doi: 10.1016/j.ccell.2017.04.008.
In this issue of Cancer Cell, Nagaraja et al. dissect the molecular mechanisms underlying therapeutic responses to transcriptional disruptors in the fatal pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). Moreover, they identify super-enhancers mediating these effects, highlighting how normal brain developmental programs can be hijacked in cancer.
在本期《癌细胞》杂志中，Nagaraja 等人剖析了导致致命性小儿脑肿瘤——弥漫性内在脑桥胶质瘤（DIPG）对转录干扰治疗产生反应的分子机制。此外，他们还鉴定了介导这些效应的超级增强子，强调了正常大脑发育程序如何在癌症中被劫持。
