β 细胞的更新与分化：慢工出细活。
β Cell Renewal versus Differentiation: Slow and Steady Wins the Race.
机构信息
Department Molecular Biology and Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas 75390-9148, USA.
出版信息
Dev Cell. 2017 May 8;41(3):223-225. doi: 10.1016/j.devcel.2017.04.017.
Pancreatic endocrine progenitor cells proliferate and transiently express the bHLH transcription factor Ngn3. In recent issues of Developmental Cell, Azzarelli et al. (2017) and Krentz et al. (2017) demonstrate how CDK phosphorylation of Ngn3 governs the switch between their renewal and differentiation. Lengthening the cell cycle allows Ngn3 accumulation, outpacing phosphorylation-induced degradation.
胰腺内分泌祖细胞增殖并短暂表达 bHLH 转录因子 Ngn3。在最近的《发育细胞》（Developmental Cell）杂志上，Azzarelli 等人（2017）和 Krentz 等人（2017）展示了 CDK 对 Ngn3 的磷酸化如何控制其更新和分化之间的转换。延长细胞周期使 Ngn3 积累，超过磷酸化诱导的降解。
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