Tucker Phebe, Pfefferbaum Betty, Nitiéma Pascal, Khan Qaiser, Aggarwal Ruchi, Walling Erin E
Dept. of Psychiatry, University of Oklahoma Health Sciences Center, WP 3440, 920 Stanton L Young Blvd., Oklahoma City, OK, United States.
Dept. of Psychiatry, University of Oklahoma Health Sciences Center, WP 3440, 920 Stanton L Young Blvd., Oklahoma City, OK, United States; Biostatistician, Management Information Systems, University of Oklahoma, Norman OK, United States.
Cytokine. 2017 Aug;96:247-252. doi: 10.1016/j.cyto.2017.04.025. Epub 2017 May 6.
Cytokines are of increasing interest as markers for stress responses, mental disorders and general health. We assessed associations of two cytokines with several factors among relocated hurricane survivors and controls.
We examined 40 relocated hurricane survivors and 40 demographically matched (frequency matching) Oklahoma controls to assess relationships of Interleukin-2 (IL-2) and Interleukin-6 (IL-6) with psychiatric diagnoses (SCID-IV), demographic variables, hurricane exposure and body mass index (BMI). Participants were predominantly African American (n=70, 87.5%).
Relocated Katrina survivors had higher proportions of current PTSD, major depression and psychiatric diagnoses than controls. Unexpectedly, exposure to Katrina with relocation was not by itself associated with differences in IL-2 or IL-6 levels. The mean IL-2 level was significantly higher in African American participants than other ethnicities (8 Caucasians, 2 Asians) and in those with a current psychiatric disorder. The mean IL-6 level was higher in females than males and in participants with any current psychiatric diagnosis. IL-6 level also correlated positively with participants' BMI.
Results suggest that cytokines studied were influenced non-specifically by the presence of a mental disorder, and by demographic variables of gender, ethnicity and BMI. Implications of these findings are discussed, as well as possible long-term impact of the identified interleukin differences on immunologic, inflammatory, neuropsychiatric and other systems.
细胞因子作为应激反应、精神障碍和总体健康的标志物，越来越受到关注。我们评估了两种细胞因子与重新安置的飓风幸存者及对照组中若干因素之间的关联。
我们研究了40名重新安置的飓风幸存者和40名在人口统计学上匹配（频率匹配）的俄克拉荷马州对照者，以评估白细胞介素-2（IL-2）和白细胞介素-6（IL-6）与精神疾病诊断（SCID-IV）、人口统计学变量、飓风暴露情况及体重指数（BMI）之间的关系。参与者主要为非裔美国人（n = 70，87.5%）。
与对照组相比，重新安置的卡特里娜飓风幸存者中当前患有创伤后应激障碍、重度抑郁症和精神疾病诊断的比例更高。出乎意料的是，经历卡特里娜飓风并重新安置本身与IL-2或IL-6水平的差异并无关联。非裔美国参与者的平均IL-2水平显著高于其他种族（8名白种人，2名亚洲人）以及当前患有精神疾病的参与者。女性的平均IL-6水平高于男性，且在任何当前患有精神疾病诊断的参与者中也是如此。IL-6水平还与参与者的BMI呈正相关。
结果表明，所研究的细胞因子受到精神障碍的存在以及性别、种族和BMI等人口统计学变量的非特异性影响。讨论了这些发现的意义，以及所确定的白细胞介素差异对免疫、炎症、神经精神和其他系统可能产生的长期影响。
