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一名接触过γ-氨基丁酸受体拮抗剂秋水仙碱硫代糖苷的婴儿出现短暂性癫痫发作。

Temporary Seizure in an Infant Who Had Been Exposed to G-Amino Butyric Acid Receptor Antagonist Thiocolchicoside.

作者信息

Havali Cengiz, Gucuyener Kivilcim, Gurkas Esra, Demir Ercan

机构信息

From the Department of Paediatric Neurology, Gazi University Faculty of Medicine, Ankara, Turkey.

出版信息

Pediatr Emerg Care. 2019 May;35(5):e96-e97. doi: 10.1097/PEC.0000000000001161.

Abstract

Seizure is the most common presentation of neurological disorder in the pediatric emergency care setting. In evaluating the child after a first seizure, the first consideration should be determining if the seizure was provoked or unprovoked. Investigation listing the causes of the first seizure is considerably long, and adverse drug reactions must be in mind. Epileptic seizures after using thiocolchicoside (TCC) have been reported in several adult patients with epilepsy and acute brain injury. We present a previously healthy 3-month-old female infant who was admitted to the emergency department with a generalized seizure after exposure to TCC. To the best of our knowledge, this is the first case of a child who had an epileptic seizure after TCC intake via breastfeeding in the literature.

摘要

癫痫发作是儿科急诊中最常见的神经系统疾病表现。在评估首次癫痫发作后的儿童时,首先应考虑确定该发作是有诱因的还是无诱因的。引发首次癫痫发作的原因清单相当长,必须考虑到药物不良反应。已有数例成年癫痫患者和急性脑损伤患者在使用秋水仙碱糖苷(TCC)后出现癫痫发作的报道。我们报告了一名此前健康的3个月大女婴,她在接触TCC后因全身性癫痫发作被送往急诊科。据我们所知,这是文献中首例通过母乳喂养摄入TCC后发生癫痫发作的儿童病例。

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