与周围性多发性神经病相关的重链和游离轻链骨髓瘤
Heavy- and free light-chain myeloma associated with peripheral polyneuropathy.
作者信息
Cotariu D, Kaufman S, Golik A, Scharf S, Zaidman J L
机构信息
Department of Biochemical Pathology, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.
出版信息
Clin Chem. 1988 Dec;34(12):2594-5.
PMID:2848651
Abstract
Peripheral polyneuropathy, a rare complication of multiple myeloma, is generally associated with heavy-chain M-proteins and, in very rare instances, with free light-chain myeloma proteins. Here we describe a case of multiple myeloma and polyneuropathy with both monoclonal IgG and free lambda light chains in the blood. The patient also had free lambda light chains in the cerebrospinal fluid and urine.
摘要
周围性多发性神经病是多发性骨髓瘤的一种罕见并发症，通常与重链M蛋白有关，在极少数情况下与游离轻链骨髓瘤蛋白有关。在此，我们描述一例血液中同时存在单克隆IgG和游离λ轻链的多发性骨髓瘤合并多发性神经病病例。该患者的脑脊液和尿液中也存在游离λ轻链。
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