[伴有自然杀伤细胞缺陷的严重慢性爱泼斯坦-巴尔病毒感染]
[Severe chronic Epstein-Barr virus infection with natural killer cell defect].
作者信息
Hartung K, Le Blanc S, Franz A, Jacobs R, Wittekind C, Bornkamm G W, Schmidt R E
机构信息
Abteilung Immunologie und Transfusionsmedizin, Medizinischen Hochschule Hannover.
出版信息
Dtsch Med Wochenschr. 1988 Dec 16;113(50):1960-3. doi: 10.1055/s-2008-1067919.
Chronic Epstein-Barr virus infection was confirmed serologically in a 27-year-old man with pneumonia, splenomegaly, pancytopenia, arthritis, neuropathy and psychological changes. Immunological tests revealed a defect in the cytotoxic activity of the natural killer cells. Treatment with high doses of acyclovir intravenously and of antimycotic drugs dramatically and lastingly improved the patient's condition.
一名27岁男性，患有肺炎、脾肿大、全血细胞减少、关节炎、神经病变和心理改变，经血清学检查确诊为慢性EB病毒感染。免疫测试显示自然杀伤细胞的细胞毒性活性存在缺陷。静脉注射高剂量阿昔洛韦和抗真菌药物治疗后，患者病情显著且持久改善。
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