吸烟对角膜内皮细胞的影响：一项针对伊朗伊斯法罕人群的横断面研究。

The effects of smoking on corneal endothelial cells: a cross-sectional study on a population from Isfahan, Iran.

作者信息

Golabchi Khodayar, Abtahi Mohammad-Ali, Salehi Ali, Jahanbani-Ardakani Hamidreza, Ghaffari Sara, Farajzadegan Ziba

机构信息

a Isfahan Eye Research Center (IERC), Feiz Eye Hospital, Isfahan University of Medical Sciences , Isfahan , Iran.

b Department of Ophthalmology , Feiz Eye Hospital, Isfahan University of Medical Sciences , Isfahan , Iran.

出版信息

Cutan Ocul Toxicol. 2018 Mar;37(1):9-14. doi: 10.1080/15569527.2017.1317783. Epub 2017 Jun 19.

DOI:10.1080/15569527.2017.1317783

PMID:28486855

Abstract

PURPOSE

The aim of this study is to compare the effect of smoking in corneal endothelial cell number and morphology by specular microscopy on a non-smoker population.

METHODS

Our cross-sectional study was performed on 150 participants from a non-smoker population. Non-contact specular microscopy (Tomey Corporation Inc., Nagoya, Japan) was performed in the center of the cornea of all subjects. The cell density (CD), average cell size (AVG), percent of hexagonality (HEX%) and central corneal thickness (CCT) were calculated and compared in both groups.

RESULTS

Totally, 76 eyes of 76 smokers and 74 eyes of 74 non-smokers were enrolled in the study from 2015 to 2016. The mean age of smokers and non-smokers were 48.61 ± 17.04 and 46.39 ± 13.02, respectively. The mean number of pack/year among the smokers was 17.36 ± 14.68. Also, the mean values of AVG and CD were significantly different for these two groups (p = 0.011 and p = 0.039, respectively). Other corneal endothelial variables did not show a significant difference between smokers and non-smokers (p > 0.05). However, smokers with severe nicotine dependency had significantly greater AVG and lower CD in comparison with the non-smokers (p = 0.004 and p = 0.013, respectively).

CONCLUSION

Our study showed that smoking can cause significant changes in some of the corneal endothelial variables, but not all of them.

摘要

目的

本研究旨在通过镜面显微镜比较吸烟对非吸烟人群角膜内皮细胞数量和形态的影响。

方法

我们对150名非吸烟人群参与者进行了横断面研究。对所有受试者的角膜中央进行非接触式镜面显微镜检查（日本名古屋多美公司）。计算并比较两组的细胞密度（CD）、平均细胞大小（AVG）、六角形细胞百分比（HEX%）和中央角膜厚度（CCT）。

结果

2015年至2016年，本研究共纳入76名吸烟者的76只眼和74名非吸烟者的74只眼。吸烟者和非吸烟者的平均年龄分别为48.61±17.04岁和46.39±13.02岁。吸烟者的平均吸烟包年数为17.36±14.68。此外，两组的AVG和CD平均值存在显著差异（分别为p = 0.011和p = 0.039）。吸烟者和非吸烟者之间的其他角膜内皮变量没有显著差异（p>0.05）。然而，与非吸烟者相比，尼古丁严重依赖的吸烟者的AVG显著更大，CD显著更低（分别为p = 0.004和p = 0.013）。