Sayin Nihat, Kara Necip, Pekel Gökhan, Altinkaynak Hasan
Department of Ophthalmology, Kanuni Sultan Suleyman Research and Training Hospital , Istanbul , Turkey .
Cutan Ocul Toxicol. 2014 Sep;33(3):201-5. doi: 10.3109/15569527.2013.832688. Epub 2013 Oct 22.
To evaluate the effect of chronic cigarette smoking on dry eye parameters, endothelial cells, and corneal thickness.
Prospective cross-sectional case series.
In this cross-sectional study, 49 eyes of 49 chronic smokers (smoker group) and 53 eyes of 53 age-matched, healthy non-smokers (non-smoker group) were enrolled. All participants underwent measurements of tear breakup time (TBUT), central corneal thickness (CCT) measurements with contact pachymeter and the Schirmer test with anesthesia. Corneal endothelial cells were evaluated by non-contact specular microscopy and photographed for analysis of cell density and hexagonality and the coefficient of variation in cell size.
The mean Schirmer score and TBUT value were significantly lower in the smoker group compared to the non-smoker group (p = 0.015) and p < 0.001, respectively). No statistically significant difference was found in the mean CCT, mean endothelial cell density, endothelial cell size, SD of size, and CV of size between smokers and non-smokers (p > 0.05). However, a lower percentage of endothelial hexagonal cells were observed in smokers than non-smokers (p < 0.001).
Our results suggest that cigarette smoking seems to affect the Schirmer score, TBUT value, and hexagonal cells of the corneal endothelium.
评估长期吸烟对干眼参数、内皮细胞和角膜厚度的影响。
前瞻性横断面病例系列研究。
在这项横断面研究中，纳入了49名慢性吸烟者的49只眼（吸烟者组）和53名年龄匹配的健康非吸烟者的53只眼（非吸烟者组）。所有参与者均接受了泪膜破裂时间（TBUT）测量、使用接触式测厚仪测量中央角膜厚度（CCT）以及麻醉下的Schirmer试验。通过非接触式镜面显微镜评估角膜内皮细胞，并拍照以分析细胞密度、六角形细胞比例和细胞大小变异系数。
吸烟者组的平均Schirmer评分和TBUT值显著低于非吸烟者组，分别为p = 0.015和p < 0.001。吸烟者与非吸烟者之间的平均CCT、平均内皮细胞密度、内皮细胞大小、大小标准差和大小变异系数均无统计学显著差异（p > 0.05）。然而，吸烟者的内皮六角形细胞百分比低于非吸烟者（p < 0.001）。
我们的结果表明，吸烟似乎会影响Schirmer评分、TBUT值和角膜内皮的六角形细胞。
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