The influence of folic acid on the picrotoxin-sensitive site of the GABAa-receptor complex.
作者信息
Van Rijn C M, Van der Velden T J, Rodrigues de Miranda J F, Feenstra M G, Hommes O R
机构信息
Dept. of Experimental Neurology, University of Nijmegen, The Netherlands.
出版信息
Epilepsy Res. 1988 May-Jun;2(3):215-8. doi: 10.1016/0920-1211(88)90058-7.
PMID:2848698
Abstract
The site of action responsible for the convulsive effect of folic acid was investigated in vitro. Folic acid (ECmax 5 x 10(-4) M) enhances the binding of the cage convulsant [3H]t-butylbicycloorthobenzoate ([3H]TBOB) to rat brain membranes, namely to 130% of control in the absence of GABA and to over 300% of control in the presence of physiological concentrations of GABA. Analysis of the binding parameters reveals that folic acid increases the apparent number of [3H]TBOB binding sites.
摘要
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