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编辑推荐——采用倾向评分模型对匹配队列中自膨式聚四氟乙烯覆膜支架与裸金属支架治疗慢性髂动脉闭塞的疗效比较

Editor's Choice - Outcomes of Self Expanding PTFE Covered Stent Versus Bare Metal Stent for Chronic Iliac Artery Occlusion in Matched Cohorts Using Propensity Score Modelling.

作者信息

Piazza M, Squizzato F, Dall'Antonia A, Lepidi S, Menegolo M, Grego F, Antonello M

机构信息

Vascular and Endovascular Surgery Clinic, Padova University, School of Medicine, Padua, Italy.

Vascular and Endovascular Surgery Clinic, Padova University, School of Medicine, Padua, Italy.

出版信息

Eur J Vasc Endovasc Surg. 2017 Aug;54(2):177-185. doi: 10.1016/j.ejvs.2017.03.019. Epub 2017 May 6.

Abstract

OBJECTIVES

The aim was to compare outcomes of self expanding PTFE covered stents (CSs) with bare metal stents (BMSs) in the treatment of iliac artery occlusions (IAOs).

METHODS

Between January 2009 and December 2015, 128 iliac arteries were stented for IAO. A CS was implanted in 78 iliac arteries (61%) and a BMS in 50 (49%). After propensity score matching, 94 limbs were selected and underwent stenting (47 for each group). Thirty day outcomes and midterm patency were compared; follow-up results were analysed with Kaplan-Meier curves.

RESULTS

Overall, iliac lesions were classified by limb as TASC B (19%), C (21%), and D (60%). Technical success was 98%. Comparing CS versus BMS, the early cumulative surgical complication rate (12% vs. 12%, p = 1.0) and 30 day mortality rate (2% vs. 2%, p = 1.0) were equivalent. At 36 months (average 23 ± 17), overall primary patency was similar between CS and BMS (87% vs. 66%, p = .06), and this finding was maintained after stratification by TASC B (p = .29) and C (p = .27), but for TASC D, CSs demonstrated a higher patency rate (CS, 88% vs. BMS, 54%; p = .03). In particular, patency was in favour of CSs for IAOs > 3.5 cm in length (p = .04), total lesion length > 6 cm (p = .04), and IAO with calcification > 75% of the arterial wall circumference (p = .01).

CONCLUSIONS

Overall, the use of self expanding CS for IAOs has similar early and midterm outcomes compared with BMS. Even if further confirmatory studies are needed, CSs seem to have higher midterm patency rates than BMSs for TASC D lesions, IAOs with a total lesion length > 6 cm, occlusion length > 3.5 cm, and calcification involving > 75% of the arterial wall circumference. These specific anatomical parameters may be useful to the operator when deciding between CS and BMS during endovascular planning.

摘要

目的

比较自膨式聚四氟乙烯覆膜支架(CS)与裸金属支架(BMS)治疗髂动脉闭塞(IAO)的疗效。

方法

2009年1月至2015年12月,128条髂动脉因IAO接受支架置入术。78条髂动脉(61%)植入CS,50条(49%)植入BMS。倾向评分匹配后,选取94条肢体进行支架置入(每组47条)。比较30天结局和中期通畅率;采用Kaplan-Meier曲线分析随访结果。

结果

总体而言,髂动脉病变按肢体分为TASC B型(19%)、C型(21%)和D型(60%)。技术成功率为98%。比较CS与BMS,早期累积手术并发症发生率(12%对12%,p = 1.0)和30天死亡率(2%对2%,p = 1.0)相当。在36个月时(平均23±17),CS与BMS的总体原发性通畅率相似(87%对66%,p = 0.06),按TASC B型(p = 0.29)和C型(p = 0.27)分层后该结果仍成立,但对于TASC D型病变,CS的通畅率更高(CS为88%,BMS为54%;p = 0.03)。特别是,对于长度>3.5 cm的IAO(p = 0.04)、总病变长度>6 cm(p = 0.04)以及钙化累及动脉壁周长>75%的IAO(p = 0.01),CS的通畅率更优。

结论

总体而言,与BMS相比,自膨式CS治疗IAO的早期和中期疗效相似。即使需要进一步的验证性研究,但对于TASC D型病变、总病变长度>6 cm的IAO、闭塞长度>3.5 cm的IAO以及钙化累及动脉壁周长>75%的IAO,CS的中期通畅率似乎高于BMS。在血管内治疗规划中,这些特定的解剖学参数可能有助于操作者在CS和BMS之间做出选择。

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