Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada.
Sci Rep. 2017 May 9;7(1):1629. doi: 10.1038/s41598-017-01406-y.
We assessed the association between depression status and prevalent and incident type 2 diabetes (T2D) as well as the interaction between depression and a genetic risk score (GS) based on 20 T2D single-nucleotide polymorphisms (SNPs) in a multi-ethnic longitudinal study. We studied 17,375 participants at risk for dysglycemia. All participants had genotypic and phenotypic data collected at baseline and 9,930 participants were followed-up for a median of 3.3 years. Normal glucose tolerance (NGT), impaired fasting glucose (IFG)/impaired glucose tolerance (IGT) and T2D statuses were determined using an oral glucose tolerance test and the 2003 American Diabetes Association criteria. Depression was diagnosed at baseline using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM IV). Multivariate logistic regression models were adjusted for age, sex, ethnicity and body-mass index and an interaction term GS X depression was added to the model. After appropriate Bonferroni correction, no significant association between depression and T2D-related traits (IFG/IGT, T2D and dysglycemia), and no significant interaction between the GS and depression status was observed at baseline or follow-up. Our longitudinal data do not support an association between depression and abnormal glycemic status. Moreover, depression does not modify the effect of T2D predisposing gene variants.
我们评估了抑郁状态与 2 型糖尿病（T2D）的现患和新发之间的相关性，以及抑郁与基于 20 个 T2D 单核苷酸多态性（SNP）的遗传风险评分（GS）之间的相互作用，这是一项多民族纵向研究。我们研究了 17375 名处于发生糖尿病前期风险的参与者。所有参与者均在基线时收集了基因型和表型数据，其中 9930 名参与者的中位随访时间为 3.3 年。采用口服葡萄糖耐量试验和 2003 年美国糖尿病协会标准确定正常糖耐量（NGT）、空腹血糖受损（IFG）/糖耐量受损（IGT）和 T2D 状态。在基线时使用精神障碍诊断和统计手册，第四版（DSM IV）诊断抑郁。调整了年龄、性别、种族和体重指数等多变量逻辑回归模型，并在模型中添加了 GS X 抑郁的交互项。经过适当的 Bonferroni 校正，在基线或随访时，抑郁与与 T2D 相关的特征（IFG/IGT、T2D 和糖代谢异常）之间没有显著相关性，GS 和抑郁状态之间也没有显著的相互作用。我们的纵向数据不支持抑郁与异常血糖状态之间存在关联。此外，抑郁不能改变 T2D 易感基因变异的作用。
