Kan C, Pedersen N L, Christensen K, Bornstein S R, Licinio J, MacCabe J H, Ismail K, Rijsdijk F
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Mol Psychiatry. 2016 Jul;21(7):903-9. doi: 10.1038/mp.2016.28. Epub 2016 Mar 29.
A bidirectional association between type 2 diabetes (T2DM) and depression has been consistently reported. Depression is associated with worse biomedical outcomes and increased mortality. The mechanisms underlying the association of T2DM with depression remain unclear. One possible question we can address is the extent to which the co-occurrence of diabetes and depression is due to correlated genetic and/or environmental risk factors. In this study, we performed structural equation model fitting to population-level data from the Swedish (n=68 606) and Danish (n=95 403) twin registries. The primary outcomes were clinical diagnosis of T2DM and depression using national hospital discharge registries. The phenotypic correlation between T2DM and depression is modest in both samples. In the Swedish sample, unique environmental effects explain a greater proportion of the covariance in males, whereas the association is primarily attributed to genetic effects in females. In the Danish sample, genetic effects account for the majority of the covariance in both males and females. Qualitative genetic sex differences are observed in both samples. We believe this is the first study to demonstrate significant genetic overlap between T2DM and depression.
2型糖尿病（T2DM）与抑郁症之间的双向关联已被持续报道。抑郁症与更差的生物医学结局及更高的死亡率相关。T2DM与抑郁症关联背后的机制仍不清楚。我们可以探讨的一个可能问题是，糖尿病和抑郁症的共病在多大程度上是由于相关的遗传和/或环境风险因素。在本研究中，我们对来自瑞典（n = 68606）和丹麦（n = 95403）双胞胎登记处的人群水平数据进行了结构方程模型拟合。主要结局是使用国家医院出院登记处对T2DM和抑郁症进行临床诊断。在两个样本中，T2DM与抑郁症之间的表型相关性都较弱。在瑞典样本中，独特的环境效应对男性协方差的解释比例更大，而在女性中，这种关联主要归因于遗传效应。在丹麦样本中，遗传效应在男性和女性中都占协方差的大部分。在两个样本中都观察到了定性的遗传性别差异。我们认为这是第一项证明T2DM与抑郁症之间存在显著遗传重叠的研究。
