Unit of Andrology and Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Urology Section, Department of Surgery, University of Catania, Catania, Italy.
J Endocrinol Invest. 2017 Nov;40(11):1209-1218. doi: 10.1007/s40618-017-0684-0. Epub 2017 May 9.
Prostatitis is a very common urogenital disease of the male with prevalence ranging from 2.2 to 9.7% worldwide. Interestingly, some recent evidences have showed a significant association between chronic prostatitis (CP) and male infertility including a detrimental effect on sperm parameters, reduction of zinc concentration on semen sperm and production of anti-semen antibodies (ASAs). The aim of the current meta-analysis was to evaluate the association between CP and alteration of semen parameters.
This analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines and we included in the final analysis 27 studies, with a total of 3241 participants, including 381 (11.75%) with chronic bacterial prostatitis (CBP), 1670 (51.53%) with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and 1190 (36.72%) controls.
CBP was associated with reduction of sperm concentration, sperm vitality, sperm total and progressive motility, while CP/CPPS was related to the reduction of semen volume, sperm concentration, sperm progressive motility and sperm normal morphology. We found that CP was significantly associated with reduced zinc concentration on seminal plasma (SMD: -20.73; p = 0.005). Finally, CP statistically increased the risk of developing ASA on seminal plasma (OR 3.26; p < 0.01).
In conclusion, chronic prostatitis showed a detrimental effect on sperm and both CPB or CP/CPPS may differently show negative impact on sperm.
前列腺炎是一种非常常见的男性泌尿生殖系统疾病，全球患病率为 2.2%至 9.7%。有趣的是，一些最近的证据表明慢性前列腺炎（CP）与男性不育之间存在显著关联，包括对精子参数、精液中锌浓度和抗精液抗体（ASAs）产生的不利影响。本荟萃分析的目的是评估 CP 与精液参数改变之间的关联。
本分析根据系统评价和荟萃分析的首选报告项目指南进行，我们最终纳入了 27 项研究，共 3241 名参与者，其中 381 名（11.75%）患有慢性细菌性前列腺炎（CBP），1670 名（51.53%）患有慢性前列腺炎/慢性骨盆疼痛综合征（CP/CPPS），1190 名（36.72%）为对照组。
CBP 与精子浓度、精子活力、精子总数和前向运动能力降低相关，而 CP/CPPS 与精液量、精子浓度、前向运动精子活力和精子正常形态减少相关。我们发现 CP 与精液中锌浓度降低显著相关（SMD：-20.73；p=0.005）。最后，CP 使精液中产生 ASA 的风险显著增加（OR 3.26；p<0.01）。
总之，慢性前列腺炎对精子有不利影响，CBP 或 CP/CPPS 可能对精子产生不同的负面影响。
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