Shang Yonggang, Liu Chengcheng, Cui Dong, Han Guangwei, Yi Shanhong
Department of Urology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
Sci Rep. 2014 Nov 28;4:7233. doi: 10.1038/srep07233.
Chronic bacterial prostatitis (CBP) is caused by bacterial infection and maintains a condition of lower urinary tract infection. It may be a cause of male infertility. However, studies showed inconsistent results regarding the effect of CBP on several parameters of semen. Hence, we conducted a meta-analysis to examine the effect of CBP on basic semen parameters. A systematic review was conducted with Medline, PubMed, EMBASE, and two Chinese databases (CNKI and WANG FANG) to identify relevant studies that involved the effect of CBP on semen parameters up to July 2014. Both RevMan5.2 and STATA 12.0 software were used for the statistical analysis. Based on the inclusion and exclusion criteria, seven studies were included. The study illustrated that sperm vitality, sperm total motility, and the percentage of progressively motile sperm from CBP patients were significantly lower than controls (SMD(95%CI) -0.81[-1.14, -0.47], -1.00[-1.28, -0.73], -0.41 [-0.70, -0.12], P<0.05, respectively). However, CBP had no significant effect on semen volume, sperm concentration and the duration of semen liquefaction. In summary, our study revealed that there was a significant negative effect of CBP on sperm vitality, sperm total motility, and the percentage of progressively motile sperm. Additional, studies with larger number of subjects are needed.
慢性细菌性前列腺炎（CBP）由细菌感染引起，可导致下尿路感染持续存在，它可能是男性不育的一个原因。然而，关于CBP对精液多项参数的影响，研究结果并不一致。因此，我们进行了一项荟萃分析，以研究CBP对精液基本参数的影响。通过检索Medline、PubMed、EMBASE以及两个中文数据库（中国知网和万方）进行系统评价，以识别截至2014年7月涉及CBP对精液参数影响的相关研究。采用RevMan5.2和STATA 12.0软件进行统计分析。根据纳入和排除标准，纳入了7项研究。研究表明，CBP患者的精子活力、精子总活力和进行性运动精子百分比显著低于对照组（标准化均数差（95%可信区间）分别为-0.81[-1.14，-0.47]、-1.00[-1.28，-0.73]、-0.41[-0.70，-0.12]，P<0.05）。然而，CBP对精液体积、精子浓度和精液液化时间没有显著影响。总之，我们的研究表明，CBP对精子活力、精子总活力和进行性运动精子百分比有显著负面影响。此外，还需要更多受试者的研究。
