Wang Yuan-Hang, Wang Fang, Zhang Lan, Lu Jia-Chun
1 GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, China.
2 The State Key Lab of Respiratory Disease, The Institute for Chemical Carcinogenesis, Collaborative Innovation Center for Environmental Toxicity, Guangzhou Medical University, Guangzhou, China.
Tumour Biol. 2017 May;39(5):1010428317706208. doi: 10.1177/1010428317706208.
Numerous studies suggested that long non-coding RNA UCA1 was highly expressed and played critical roles in the development and progression of various cancerous tissues and cells. However, little is known about the association between UCA1 and tumor lymph node metastasis. In our study, a systematic review was conducted to evaluate the association between UCA1 expression and tumor lymph node metastasis and explore whether UCA1 can be a potential molecular marker for predicting the multiple tumor lymph node metastasis. The meta-analysis result showed that the number of lymph node metastasis in different tumorous types of UCA1 high-expression group was significantly higher compared with UCA1 low-expression group (pooled odds ratio = 2.13, 95% confidence interval: 1.60-2.84, p < 0.05). To verify whether the above result was still valid in specific tumor type, we conducted a meta-analysis including four articles on colorectal cancer (pooled odds ratio = 2.07, 95% confidence interval: 1.28-3.34, p < 0.05). Based on the existing results, it can be explained that the long non-coding RNA UCA1 was significantly associated with lymph node metastasis and both the results revealed that compared with UCA1 low-expression group, the lymph node metastasis rate of UCA1 high-expression group was statistically significantly elevated. Therefore, long non-coding RNA UCA1 has the potential of being a biological marker for predicting lymph node metastasis.
众多研究表明，长链非编码RNA UCA1在多种癌组织和癌细胞的发生发展过程中高表达并发挥关键作用。然而，关于UCA1与肿瘤淋巴结转移之间的关联却知之甚少。在我们的研究中，进行了一项系统评价，以评估UCA1表达与肿瘤淋巴结转移之间的关联，并探讨UCA1是否可作为预测多种肿瘤淋巴结转移的潜在分子标志物。荟萃分析结果显示，UCA1高表达组不同肿瘤类型的淋巴结转移数量显著高于UCA1低表达组（合并比值比=2.13，95%置信区间：1.60-2.84，p<0.05）。为验证上述结果在特定肿瘤类型中是否仍然有效，我们进行了一项包括四篇关于结直肠癌文章的荟萃分析（合并比值比=2.07，95%置信区间：1.28-3.34，p<0.05）。基于现有结果，可以解释长链非编码RNA UCA1与淋巴结转移显著相关，且两项结果均显示，与UCA1低表达组相比，UCA1高表达组的淋巴结转移率在统计学上显著升高。因此，长链非编码RNA UCA1具有作为预测淋巴结转移生物标志物的潜力。
