Janssens A Cecile Jw, Bunnik Eline M, Burke Wylie, Schermer Maartje Hn
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Department of Clinical Genetics/EMGO Institute for Health and Care Research, Section Community Genetics, VU University Medical Center, Amsterdam, The Netherlands.
Eur J Hum Genet. 2017 Jun;25(7):789-790. doi: 10.1038/ejhg.2017.63. Epub 2017 May 10.
Genetic testing for personalizing diet and wellness programs is performed without extensive counseling that informs about the potential implications of knowing one's genotype status. Genetic counseling seems redundant for genes that impact the effect of diet on biomarkers such as cholesterol and blood pressure, but the same genes may have pleiotropic effects that cannot be ignored. A well-known example is the APOE gene, which is implicated in cholesterol regulation and is a major risk factor for Alzheimer's disease. Not fully informing participants about the major pleiotropic effects of genes has ethical implications and invalidates informed consent.
用于个性化饮食和健康计划的基因检测在没有广泛咨询的情况下进行，这种咨询应告知了解个人基因型状态的潜在影响。对于影响饮食对胆固醇和血压等生物标志物作用的基因，基因咨询似乎多余，但相同的基因可能具有不可忽视的多效性作用。一个著名的例子是APOE基因，它与胆固醇调节有关，是阿尔茨海默病的主要危险因素。没有充分告知参与者基因的主要多效性作用具有伦理意义，并使知情同意无效。
