抗精神病药物与心血管不良事件之间的关联：一项系统综述。
Association between antipsychotics and cardiovascular adverse events: A systematic review.
作者信息
Silva Ana Amancio Santos Da, Ribeiro Marina Viegas Moura Rezende, Sousa-Rodrigues Célio Fernando de, Barbosa Fabiano Timbó
机构信息
MSc in Health Sciences, Universidade Federal de Alagoas (Ufal), Maceió, AL, Brazil.
PhD of the Department of Anatomy, Ufal, Maceió, AL, Brazil.
出版信息
Rev Assoc Med Bras (1992). 2017 Mar;63(3):261-267. doi: 10.1590/1806-9282.63.03.261.
OBJECTIVE
: Determine whether there is an association between the risk of cardiovascular adverse events and the use of antipsychotic agents.
METHOD
: Analysis of original articles retrieved from the following databases: LILACS, PubMed, Cochrane Controlled Trials Clinical Data Bank (CENTRAL) and PsycINFO, without language restriction, dated until November 2015. After screening of 2,812 studies, three cohort original articles were selected for quality analysis.
RESULTS
: 403,083 patients with schizophrenia and 119,015 participants in the control group data were analyzed. The occurrence of cardiovascular events observed in the articles was: 63.5% (article 1), 13.1% (article 2) and 24.95% (article 3) in the group of treated schizophrenic patients, and 46.2%, 86.9% and 24.9%, respectively, in the control groups.
CONCLUSION
: Clinical heterogeneity among the studies led to a provisional response and made it impossible to perform the meta-analysis, although the articles demonstrate an association between cardiovascular adverse events and the use of antipsychotics. More quality clinical trials are needed to support this evidence.
目的
确定心血管不良事件风险与抗精神病药物使用之间是否存在关联。
方法
分析从以下数据库检索到的原始文章：拉丁美洲及加勒比地区卫生科学数据库（LILACS）、医学期刊数据库（PubMed）、考克兰对照试验临床数据库（CENTRAL）和心理学文摘数据库（PsycINFO），不限语言，截至2015年11月。在筛选2812项研究后，选择了3篇队列原始文章进行质量分析。
结果
分析了403083例精神分裂症患者和119015例对照组参与者的数据。文章中观察到的心血管事件发生率在接受治疗的精神分裂症患者组中分别为：63.5%（文章1）、13.1%（文章2）和24.95%（文章3），在对照组中分别为46.2%、86.9%和24.9%。
结论
尽管文章表明心血管不良事件与抗精神病药物的使用之间存在关联，但研究之间的临床异质性导致了初步的反应，无法进行荟萃分析。需要更多高质量的临床试验来支持这一证据。
Zotero 插件