铁/铜介导的一锅酮合成。
Fe/Cu-Mediated One-Pot Ketone Synthesis.
机构信息
Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
出版信息
Org Lett. 2017 May 19;19(10):2766-2769. doi: 10.1021/acs.orglett.7b01128. Epub 2017 May 10.
An Fe/Cu-mediated one-pot ketone synthesis was reported. Unlike Ni- and Pd-mediated one-pot ketone syntheses, the reported Fe/Cu-mediated method allowed selective activation and coupling of alkyl iodides over vinyl iodides. The newly developed one-pot ketone synthesis was applied to a synthesis of vinyl iodide/ketone 13, the left half of halichondrin B, as well as vinyl iodide/ketone 8a, the C20-C26 building block of halichondrins.
报道了一种 Fe/Cu 介导的一锅酮合成方法。与 Ni 和 Pd 介导的一锅酮合成方法不同，所报道的 Fe/Cu 介导方法允许对碘化烷基和碘化乙烯进行选择性活化和偶联。新开发的一锅酮合成方法被应用于 halichondrin B 的左半部分即 vinyl iodide/ketone 13，以及 halichondrins 的 C20-C26 构建块 vinyl iodide/ketone 8a 的合成。
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