Weill B J, Menkès C J, Cormier C, Louvel A, Dougados M, Houssin D
Rheumatology Department, Hôpital Cochin, Paris, France.
J Rheumatol. 1988 Sep;15(9):1447-9.
Danazol, an inhibitor of pituitary gonadotropin, has been proposed in the treatment of systemic lupus erythematosus (SLE). We report the case of a female patient with SLE in whom a hepatocellular carcinoma was discovered after 4 years of treatment with danazol. Except for 3 days of hypochondrium pain, there were neither clinical signs of liver tumor nor biological abnormalities. An ultrasonography showed 2 tumors of the liver. At histological examination after surgery, one of the tumors was found to be a benign adenoma, while the other was a well differentiated hepatocellular carcinoma. When longterm danazol therapy is required, ultrasonography may be useful for early tumor detection.
达那唑是一种垂体促性腺激素抑制剂，已被用于治疗系统性红斑狼疮（SLE）。我们报告了一例SLE女性患者，在用达那唑治疗4年后发现肝细胞癌。除了3天的季肋部疼痛外，既没有肝肿瘤的临床体征，也没有生物学异常。超声检查显示肝脏有2个肿瘤。术后组织学检查发现，其中一个肿瘤是良性腺瘤，另一个是高分化肝细胞癌。当需要长期使用达那唑治疗时，超声检查可能有助于早期肿瘤检测。
