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处方阿片类药物滥用症状的风险因素:老年人与年轻成年患者有差异吗?

Risk Factors for Symptoms of Prescription Opioid Misuse: Do Older Adults Differ from Younger Adult Patients?

作者信息

Cochran Gerald, Rosen Daniel, McCarthy Rebecca M, Engel Rafael J

机构信息

a School of Social Work, University of Pittsburgh , School of Medicine, Department of Psychiatry , Pittsburgh , Pennsylvania , USA.

b School of Social Work, University of Pittsburgh , Pittsburgh , Pennsylvania , USA.

出版信息

J Gerontol Soc Work. 2017 Aug-Oct;60(6-7):443-457. doi: 10.1080/01634372.2017.1327469. Epub 2017 May 10.

DOI:10.1080/01634372.2017.1327469
PMID:28489491
Abstract

Limited research is available regarding the health risks associated with opioid medication misuse among middle age (50-64 years) and older adults (65 and older). Understanding the misuse symptom risk profiles of these populations has potential to advance the national opioid epidemic response. A survey was conducted in four community pharmacies in southwestern Pennsylvania among adult, non-cancer patients filling opioid medications (N = 318) regarding opioid medication misuse symptoms and misuse risk factors. Descriptive and multivariate statistical analyses compared respondent characteristics, misuse symptoms, and misuse risks among those 65 and older, 50 to 64, and those less than 50 years old. Those 65 and older (Incidence Rate Ratio [IRR] = 2.4, 95% CI = 1.46-3.95) and those 50 to 64 years (IRR = 1.26, 95% CI = 1.03-1.54) who reported illicit drug use had increased rates of misuse symptoms. Those 50-64 with posttraumatic stress disorder also had an increased rate of misuse symptoms (IRR = 1.29, 95% CI = 1.08-1.54). Misuse behaviors of those 65 and older and 50-64 involved shortening time between dosages (≥65 = 11.4%, 50-64 = 27.6%), taking higher dosages than prescribed (≥65 = 11.4%, 50-64 = 13.6%), and early refills (≥11.8%, 50-64 = 12.7%). Gerontological social workers must continue to work to understand and identify individuals engaged in misuse in order to develop and provide age appropriate care.

摘要

关于中年(50 - 64岁)和老年人(65岁及以上)阿片类药物滥用相关的健康风险,现有研究有限。了解这些人群的滥用症状风险概况,有可能推动全国应对阿片类药物流行的工作。在宾夕法尼亚州西南部的四家社区药房,对开具阿片类药物的成年非癌症患者(N = 318)进行了一项关于阿片类药物滥用症状和滥用风险因素的调查。描述性和多变量统计分析比较了65岁及以上、50至64岁以及50岁以下人群的受访者特征、滥用症状和滥用风险。报告有非法药物使用情况的65岁及以上人群(发病率比[IRR] = 2.4,95%置信区间 = 1.46 - 3.95)和50至64岁人群(IRR = 1.26,95%置信区间 = 1.03 - 1.54),其滥用症状发生率有所增加。患有创伤后应激障碍的50 - 64岁人群,其滥用症状发生率也有所增加(IRR = 1.29,95%置信区间 = 1.08 - 1.54)。65岁及以上和50 - 64岁人群的滥用行为包括缩短给药间隔时间(≥65岁 = 11.4%,50 - 64岁 = 27.6%)、服用高于处方剂量的药物(≥65岁 = 11.4%,50 - 64岁 = 13.6%)以及提前续方(≥65岁 = 11.8%,50 - 64岁 = 12.7%)。老年社会工作者必须继续努力了解和识别有滥用行为的个体,以便制定并提供适合其年龄的护理。

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