脑室内注射阿片肽对清醒大鼠基础血清肾上腺素水平的影响。
Effect of intracerebroventricular administration of opioid peptides on basal serum adrenaline levels in conscious rats.
作者信息
Nakamura M, Kamata K, Inoue H, Inaba M
机构信息
Department of Pharmacology, Kyorin University School of Medicine, Tokyo, Japan.
出版信息
Jpn J Pharmacol. 1988 Jun;47(2):151-7. doi: 10.1254/jjp.47.151.
It is considered that adrenomedullary secretion of adrenaline is centrally regulated by various endogenous substances. Recently, opioid peptides have been reported as one of this group of endogenous substances. However, the receptor through which these endogenous opioid peptides regulate adrenomedullary adrenaline secretion has not been elucidated. In the present study, various opioid peptides were administered intracerebroventricularly in conscious, unrestrained rats, and blood catecholamine levels were measured at various periods to determine which cerebral opioid peptide receptor is involved in the mechanism of basal adrenomedullary adrenaline secretion. The results indicate that delta-receptor stimulation has a positive effect on basal adrenomedullary adrenaline secretion, while mu- and kappa-receptors are not involved in this mechanism.
人们认为，肾上腺髓质肾上腺素的分泌受多种内源性物质的中枢调节。最近，阿片肽被报道为这类内源性物质之一。然而，这些内源性阿片肽调节肾上腺髓质肾上腺素分泌所通过的受体尚未阐明。在本研究中，将各种阿片肽脑室内注射给清醒、自由活动的大鼠，并在不同时间段测量血儿茶酚胺水平，以确定哪种脑阿片肽受体参与基础肾上腺髓质肾上腺素分泌机制。结果表明，δ受体刺激对基础肾上腺髓质肾上腺素分泌有正向作用，而μ受体和κ受体不参与此机制。
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