Brito Jessyca S, Borges Natália A, Esgalhado Marta, Magliano D''Angelo C, Soulage Christophe O, Mafra Denise
Cardiovascular Sciences Graduate Program, Federal University Fluminense (UFF), Niterói, Brazil.
Nephron. 2017;137(1):1-7. doi: 10.1159/000476074. Epub 2017 May 11.
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in the expression of xenobiotic-metabolizing enzymes, inflammatory cytokines and adhesion molecules. Uremic toxins such as indoxyl sulfate and indole acetic acid are derived from tryptophan fermentation by gut microbiota; they accumulate in patients with chronic kidney disease (CKD) on haemodialysis and have recently emerged as potent ligands of AhR. Therefore, AhR can serve as a mediator in inflammation and cardiovascular diseases in these patients. This review discusses current data that support a link between AhR activation and uremic toxins from gut microbiota in CKD.
芳烃受体（AhR）是一种配体激活的转录因子，参与外源性代谢酶、炎性细胞因子和黏附分子的表达。诸如硫酸吲哚酚和吲哚乙酸等尿毒症毒素源自肠道微生物群对色氨酸的发酵；它们在接受血液透析的慢性肾脏病（CKD）患者体内蓄积，并且最近已成为AhR的强效配体。因此，AhR可作为这些患者炎症和心血管疾病的介质。本综述讨论了支持CKD中AhR激活与肠道微生物群产生的尿毒症毒素之间存在联系的现有数据。
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