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安大略远程医疗计划中患者血压变化:一项观察性纵向队列研究。

Changes in blood pressure among patients in the Ontario Telehomecare programme: An observational longitudinal cohort study.

机构信息

1 Toronto Health Economics and Technology Assessment (THETA) Collaborative, Toronto General Hospital Research Institute, University Health Network, Canada.

2 Dalla Lana School of Public Health, University of Toronto, Canada.

出版信息

J Telemed Telecare. 2018 Jul;24(6):420-427. doi: 10.1177/1357633X17706286. Epub 2017 May 10.

DOI:10.1177/1357633X17706286
PMID:28490229
Abstract

Background The objective of this study was to investigate the changes in blood pressure among patients enrolled in the Telehomecare programme in Ontario, Canada. Methods This observational study utilised a prospective longitudinal cohort design, including patients with heart failure and chronic obstructive pulmonary disease enrolled in the Ontario Telehomecare programme from July 2012 to July 2015. The outcome of interest was change in mean (biweekly) systolic and diastolic blood pressure levels over a six-month period. Patient data were extracted from the Ontario Telemedicine Network database, and analysed using generalised linear mixed model procedures. Results Overall, we analysed data for 3513 patients. Patients were on average 74.1 ± 11.4 years of age; almost half were men, 62% had heart failure, 55% chronic obstructive pulmonary disease and 29% diabetes. At baseline, the mean systolic and diastolic blood pressure levels were 130.4 ± 19.1 mmHg and 72.2 ± 12.5 mmHg for the total sample. At six months, the adjusted reduction in systolic and diastolic blood pressure values were 4.0 mmHg (95% confidence interval: -4.5 to -3.5) and 2.7 mmHg (95% confidence interval: -3.1 to -2.4), respectively. In a subgroup of 1220 patients with uncontrolled blood pressure at baseline (systolic/diastolic blood pressure of 150.7 ± 10.2 mmHg/80.2 ± 13.5 mmHg) the adjusted reduction in systolic blood pressure was 12.5 mmHg (95% confidence interval: -13.4 to -11.6) and in diastolic blood pressure was 7.1 mmHg (95% confidence interval: -7.8 to -6.5) over the six-month period. Conclusions Blood pressure levels were significantly reduced in patients enrolled in the Telehomecare programme, with changes being more pronounced in patients with uncontrolled blood pressure. The sustainability of decreased blood pressure on other clinical outcomes needs further evaluation.

摘要

背景

本研究旨在调查加拿大安大略省远程医疗计划中入组患者的血压变化情况。

方法

这是一项观察性研究,采用前瞻性纵向队列设计,纳入 2012 年 7 月至 2015 年 7 月期间参加安大略省远程医疗计划的心力衰竭和慢性阻塞性肺疾病患者。主要结局为 6 个月期间平均(每两周)收缩压和舒张压水平的变化。从安大略远程医疗网络数据库中提取患者数据,采用广义线性混合模型进行分析。

结果

共分析了 3513 例患者的数据。患者平均年龄为 74.1±11.4 岁,近一半为男性,62%有心力衰竭,55%有慢性阻塞性肺疾病,29%有糖尿病。基线时,全样本的平均收缩压和舒张压分别为 130.4±19.1mmHg 和 72.2±12.5mmHg。6 个月时,收缩压和舒张压的调整后下降值分别为 4.0mmHg(95%置信区间:-4.5 至-3.5)和 2.7mmHg(95%置信区间:-3.1 至-2.4)。在基线血压未控制的 1220 例患者亚组中(收缩压/舒张压为 150.7±10.2mmHg/80.2±13.5mmHg),收缩压的调整后下降值为 12.5mmHg(95%置信区间:-13.4 至-11.6),舒张压为 7.1mmHg(95%置信区间:-7.8 至-6.5)。

结论

参加远程医疗计划的患者血压显著降低,血压未控制的患者变化更为明显。降低的血压对其他临床结局的可持续性需要进一步评估。

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