Lim Chul-Hyun, Lee In Seok, Jun Byoung Yeon, Kim Jin Su, Cho Yu Kyung, Park Jae Myung, Roh Sang Young, Lee Myung Ah, Kim Sang Woo, Choi Myung-Gyu
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Korean J Intern Med. 2017 May;32(3):452-458. doi: 10.3904/kjim.2015.232. Epub 2016 Mar 29.
BACKGROUND/AIMS: Neuroendocrine tumors (NETs) may originate from heterogeneous neuroendocrine cells. The incidence is increasing worldwide, and World Health Organization (WHO) updated its classification in 2010. We investigated clinical characteristics of gastroenteropancreatic NETs in a single center.
Clinicopathologic characteristics of patients with pathologically confirmed gastroenteropancreatic NET in Seoul St. Mary Hospital from March 2009 to August 2011 were retrospectively analyzed. The grade and stage were determined according to WHO 2010 classification and TNM Staging System for Neuroendocrine Tumors (7th ed., 2010) of American Joint Committee on Cancer.
One hundred and twenty-five patients (median age, 50; male, 61.3%) were analyzed. Among 100,000 patients who visited the hospital, incidence was 24.1. Only two patients (1.6%) had a functional NET. The rectum (n = 99, 79.8%) was most common primary site and found in early stage. The prevalence by stages was 84.7% stage I, 8.9% stage IV, 4.8% stage II, and 1.6% stage III. The pathology grading was 74.5% grade 1, 12.7% grade 2, and 12.7% grade 3. Tumor stage correlated positively with pathologic grade (Spearman's rank correlation coefficient, 0.644).
Wide range of clinicopathological features of Korean gastroenteropancreatic NETs were demonstrated using WHO 2010 classification. Rectal NET was most frequent and found in early stage.
背景/目的：神经内分泌肿瘤（NETs）可能起源于异质性神经内分泌细胞。其发病率在全球范围内呈上升趋势，世界卫生组织（WHO）于2010年更新了其分类。我们在单一中心调查了胃肠胰神经内分泌肿瘤的临床特征。
回顾性分析2009年3月至2011年8月在首尔圣母医院经病理确诊的胃肠胰神经内分泌肿瘤患者的临床病理特征。根据WHO 2010分类和美国癌症联合委员会的神经内分泌肿瘤TNM分期系统（第7版，2010年）确定分级和分期。
分析了125例患者（中位年龄50岁；男性占61.3%）。在100000例就诊患者中，发病率为24.1。仅有2例患者（1.6%）患有功能性神经内分泌肿瘤。直肠（n = 99，79.8%）是最常见的原发部位，且多在早期发现。各分期的患病率分别为：I期84.7%，IV期8.9%，II期4.8%，III期1.6%。病理分级为1级占74.5%，2级占12.7%，3级占12.7%。肿瘤分期与病理分级呈正相关（Spearman等级相关系数为0.644）。
采用WHO 2010分类展示了韩国胃肠胰神经内分泌肿瘤广泛的临床病理特征。直肠神经内分泌肿瘤最为常见且多在早期发现。
