结直肠癌类癌肿瘤的临床特征。
Clinical characteristics of colorectal carcinoid tumors.
出版信息
J Korean Soc Coloproctol. 2011 Feb;27(1):17-20. doi: 10.3393/jksc.2011.27.1.17. Epub 2011 Feb 28.
PURPOSE
The carcinoid tumor was recently categorized as a malignant disease due to its possibility of metastasis. This study was aimed to investigate the clinical characteristics and the metastatic rate of colorectal carcinoid tumors.
METHODS
Charts were reviewed for 502 patients diagnosed with and treated for colorectal carcinoid tumors between January 2006 and December 2009. The location, size, depth and metastatic status of the tumors were collected.
RESULTS
Including 24 synchronous tumors from 12 patients, 514 carcinoid tumors were removed. Most of them were found in the rectum (97.3%). The male-to-female ratio was 1.38 to 1, and mean age was 50.2 ± 11.4 years. The mean tumor size was 5.8 ± 3.6 mm. Less than 10-mm-sized tumors had a 1.95% lymph node metastatic rate; tumors with sizes from 10 mm to 20 mm and larger than 20 mm had 23.5% and 50% lymph node metastatic rates, respectively. Two cases had distant metastasis; one with a 22-mm-sized tumor metastasized to the liver, and the other with a 20-mm-sized tumor metastasized to the peritoneum. Among 414 patients who completed metastatic studies, 93.8% were classified as stage I, 0.9% as stage II, 4.8% as stage III and 0.5% as stage IV.
CONCLUSION
Colorectal carcinoid tumors smaller than 10 mm have a low rate of lymph node metastasis, but those sized 10 mm or larger incur significant risk. Further investigation regarding additional risk factors should be done to develop proper treatment guidelines for these tumors.
目的
由于类癌肿瘤有转移的可能性，最近它被归类为恶性疾病。本研究旨在调查结直肠类癌肿瘤的临床特征和转移率。
方法
回顾了2006年1月至2009年12月期间502例被诊断并接受治疗的结直肠类癌肿瘤患者的病历。收集了肿瘤的位置、大小、深度和转移状态。
结果
包括来自12例患者的24个同步肿瘤，共切除514个类癌肿瘤。其中大部分位于直肠（97.3%）。男女比例为1.38比1，平均年龄为50.2±11.4岁。平均肿瘤大小为5.8±3.6毫米。小于10毫米大小的肿瘤淋巴结转移率为1.95%；大小在10毫米至20毫米之间和大于20毫米的肿瘤淋巴结转移率分别为23.5%和50%。2例发生远处转移；1例22毫米大小的肿瘤转移至肝脏，另1例20毫米大小的肿瘤转移至腹膜。在完成转移研究的414例患者中，93.8%被归类为I期，0.9%为II期，4.8%为III期，0.5%为IV期。
结论
小于10毫米的结直肠类癌肿瘤淋巴结转移率低，但大小为10毫米或更大的肿瘤有显著风险。应进一步研究其他风险因素，以制定针对这些肿瘤的适当治疗指南。
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