Gonzalez-Brito A, Reiter R J, Tannenbaum M G, Jones D J
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.
Neurosci Lett. 1988 Oct 17;92(3):330-4. doi: 10.1016/0304-3940(88)90612-x.
Bilateral adrenalectomy, like chronic pineal denervation by means of superior cervical ganglionectomy, induced an increase in the morning levels of [125I]iodopindolol (IPIN) binding to rat pineal membranes; this change may be related to the reduced input of catecholamines to the pinealocytes as suggested by the decrease in nocturnal pineal melatonin synthesis previously reported in adrenalectomized rats. Castrated rats did not show changes in IPIN binding to pineal membranes when measured either at middark or in chronically superior cervical ganglionectomized rats, suggesting that the regulation of pineal beta-adrenergic receptors is independent from gonadal control.
双侧肾上腺切除术，如同通过颈上神经节切除术进行慢性松果体去神经支配一样，会导致大鼠松果体膜上[125I]碘吲哚洛尔（IPIN）结合的早晨水平升高；这种变化可能与儿茶酚胺对松果体细胞输入减少有关，正如先前报道的肾上腺切除大鼠夜间松果体褪黑素合成减少所表明的那样。阉割大鼠在午夜或慢性颈上神经节切除大鼠中测量时，松果体膜上的IPIN结合未显示变化，这表明松果体β-肾上腺素能受体的调节独立于性腺控制。
