Głażewska Edyta Katarzyna, Niczyporuk Marek, Ławicki Sławomir, Szmitkowski Maciej, Donejko Magdalena, Zajkowska Monika, Będkowska Grażyna Ewa, Przylipiak Andrzej
Department of Esthetic Medicine.
Department of Biochemical Diagnostics.
Ther Clin Risk Manag. 2017 Apr 27;13:575-582. doi: 10.2147/TCRM.S125595. eCollection 2017.
Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are thought to be associated with the pathogenesis and spread of psoriatic disease. This study was designed to investigate the plasma levels of MMP-3, MMP-9 and TIMP-3 in plaque psoriasis patients prior to and following a course of ultraviolet B narrowband treatment with respect to disease advancement.
Plasma samples of 49 patients suffering from plaque psoriasis and 40 healthy volunteers were evaluated. Concentrations of MMP-3, MMP-9 and TIMP-3 were determined using enzyme-linked immunosorbent assay, while Psoriasis Area and Severity Index was used to define disease advancement.
Plasma levels of MMP-3, MMP-9 and TIMP-3 were significantly elevated in psoriasis patients compared to healthy individuals. A course of ultraviolet B narrowband treatment resulted in a significant decline in the studied metalloproteinases. Furthermore, the concentration of selected tissue inhibitors was negatively correlated with baseline Psoriasis Area and Severity Index score.
Our research highlights the meaningful role of MMP-3, MMP-9 and TIMP-3 in psoriasis pathogenesis and clearance of disease symptoms. Furthermore, plasma levels of the analyzed metalloproteinases seem to be a valuable psoriasis biomarker.
基质金属蛋白酶（MMPs）及其组织抑制剂（TIMPs）被认为与银屑病的发病机制和扩散有关。本研究旨在调查斑块状银屑病患者在进行一个疗程的窄谱中波紫外线治疗前后血浆中MMP - 3、MMP - 9和TIMP - 3的水平与疾病进展的关系。
对49例斑块状银屑病患者和40名健康志愿者的血浆样本进行评估。采用酶联免疫吸附测定法测定MMP - 3、MMP - 9和TIMP - 3的浓度，同时使用银屑病面积和严重程度指数来定义疾病进展。
与健康个体相比，银屑病患者血浆中MMP - 3, MMP - 9和TIMP - 3水平显著升高。一个疗程的窄谱中波紫外线治疗导致所研究的金属蛋白酶显著下降。此外，所选组织抑制剂的浓度与基线银屑病面积和严重程度指数评分呈负相关。
我们的研究突出了MMP - 3、MMP - 9和TIMP - 3在银屑病发病机制和疾病症状清除中的重要作用。此外，所分析的金属蛋白酶的血浆水平似乎是一种有价值的银屑病生物标志物。
