Layne Elizabeth A, Graham Melissa
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
JFMS Open Rep. 2016 Feb 3;2(1):2055116915625356. doi: 10.1177/2055116915625356. eCollection 2016 Jan-Jun.
A 9-year-old spayed female domestic shorthair cat was examined for swelling of the right upper lip. The cat had been receiving oral ciclosporin A for eosinophilic plaques. The swelling appeared clinically and cytologically consistent with an abscess; exudate was cultured and treatment consisted of antibiotic therapy and surgical curettage. Five months of antibiotic therapy with three separate surgical treatments resulted in minimal improvement; three separate biopsy samples demonstrated epithelial cysts with severe dermal inflammation. Swelling and drainage of purulent material from the affected lip persisted and progressed to involve the left upper lip. Euthanasia was elected 13 months after initial examination due to disease progression. On necropsy, histopathology demonstrated multiple isthmus cysts intermixed with squamous cell carcinoma (SCC).
The clinical and histopathologic features were unusual for feline cutaneous SCC. The cystic nature and lack of epidermal involvement suggest the tumor arose from non-epidermal squamous cells such as follicular isthmus or ductal epithelium. There is a pattern of SCC recognized in human renal transplant patients with features of epidermal inclusion cysts. These features have not been previously reported in SCC from a cat.
一只9岁已绝育的雌性家养短毛猫因右上唇肿胀接受检查。该猫一直在口服环孢素A治疗嗜酸性斑块。临床和细胞学检查显示肿胀与脓肿相符；对渗出物进行培养，治疗包括抗生素治疗和手术刮除。经过五个月的抗生素治疗和三次单独的手术治疗，改善甚微；三次单独的活检样本显示为上皮囊肿伴严重的皮肤炎症。患侧唇部的肿胀和脓性物质引流持续存在，并发展至累及左上唇。由于病情进展，在初次检查13个月后选择实施安乐死。尸检时，组织病理学显示多个峡部囊肿与鳞状细胞癌（SCC）混合存在。
猫皮肤SCC的临床和组织病理学特征并不常见。囊肿性质以及未累及表皮提示肿瘤起源于非表皮鳞状细胞，如毛囊峡部或导管上皮。在有表皮包涵体囊肿特征的人类肾移植患者中已确认存在一种SCC模式。这些特征此前在猫的SCC中尚未见报道。
