科学政策选择与二噁英暴露相关的癌症风险评估
Science policy choices and the estimation of cancer risk associated with exposure to TCDD.
作者信息
Gough M
机构信息
Center for Risk Management, Resources for the Future, Washington, D.C. 20036.
出版信息
Risk Anal. 1988 Sep;8(3):337-42. doi: 10.1111/j.1539-6924.1988.tb00496.x.
United States regulatory agencies use no-threshold models for estimating carcinogenic risks. Other countries use no-threshold models for carcinogens that are genotoxic and threshold models for carcinogens that are not genotoxic, such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD or "dioxin"). The U.S. Environmental Protection Agency has proposed a revision of the carcinogenic potency estimate for TCDD that is based on neither a threshold nor a no-threshold model; instead, it is a compromise between risk numbers generated by the two irreconcilably different models. This paper discusses the revision and its implications.
美国监管机构使用无阈值模型来估计致癌风险。其他国家对具有基因毒性的致癌物使用无阈值模型，而对不具有基因毒性的致癌物（如2,3,7,8-四氯二苯并对二恶英（TCDD或“二恶英”））使用阈值模型。美国环境保护局已提议对TCDD的致癌效力估计进行修订，该修订既不基于阈值模型也不基于无阈值模型；相反，它是由两种截然不同的模型得出的风险数值之间的折衷。本文讨论了该修订及其影响。
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