一名长QT综合征患者在孕期及产后QT间期时长正常化，这是由于性激素对心脏复极的影响。 - Suppr

Normalization of QT interval duration in a long QT syndrome patient during pregnancy and the postpartum period due to sex hormone effects on cardiac repolarization.

作者信息

Odening Katja E, Koren Gideon, Kirk Malcolm

机构信息

Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island.

Heart Center University of Freiburg, Department of Cardiology and Angiology I, Freiburg, Germany.

出版信息

HeartRhythm Case Rep. 2016 Mar 2;2(3):223-227. doi: 10.1016/j.hrcr.2015.12.012. eCollection 2016 May.

DOI:10.1016/j.hrcr.2015.12.012

PMID:28491674

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5419752/

Abstract

摘要

相似文献

Normalization of QT interval duration in a long QT syndrome patient during pregnancy and the postpartum period due to sex hormone effects on cardiac repolarization.

HeartRhythm Case Rep. 2016 Mar 2;2(3):223-227. doi: 10.1016/j.hrcr.2015.12.012. eCollection 2016 May.

Influence of Pregnancy in Patients With Congenital Long QT Syndrome.

Cardiol Rev. 2017 Jul/Aug;25(4):197-201. doi: 10.1097/CRD.0000000000000108.

Influence of pregnancy on the risk for cardiac events in patients with hereditary long QT syndrome. LQTS Investigators.

Circulation. 1998 Feb 10;97(5):451-6. doi: 10.1161/01.cir.97.5.451.

Sex differences in ventricular repolarization: from cardiac electrophysiology to Torsades de Pointes.

Fundam Clin Pharmacol. 2004 Apr;18(2):139-51. doi: 10.1111/j.1472-8206.2004.00230.x.

Non-genomic action of sex steroid hormones and cardiac repolarization.

Biol Pharm Bull. 2013;36(1):8-12. doi: 10.1248/bpb.b212021.

Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart.

Circulation. 1996 Sep 15;94(6):1471-4. doi: 10.1161/01.cir.94.6.1471.

Sex hormonal regulation of cardiac ion channels in drug-induced QT syndromes.

Pharmacol Ther. 2016 Dec;168:23-28. doi: 10.1016/j.pharmthera.2016.09.004. Epub 2016 Sep 4.

Gender and the relationship between ventricular repolarization and cardiac cycle length during 24-h Holter recordings.

Eur Heart J. 1997 Jun;18(6):1000-6. doi: 10.1093/oxfordjournals.eurheartj.a015357.

Electro-mechanical dysfunction in long QT syndrome: Role for arrhythmogenic risk prediction and modulation by sex and sex hormones.

Prog Biophys Mol Biol. 2016 Jan;120(1-3):255-69. doi: 10.1016/j.pbiomolbio.2015.12.010. Epub 2015 Dec 21.

Invited commentary: sex-steroid hormones and QT-interval duration.

Am J Epidemiol. 2011 Aug 15;174(4):412-5. doi: 10.1093/aje/kwr170. Epub 2011 Jul 18.

引用本文的文献

Long QT Interval Syndrome and Female Sex-Review and Case Report.

Reports (MDPI). 2025 Mar 17;8(1):32. doi: 10.3390/reports8010032.

Long QT Syndrome Management during and after Pregnancy.

Medicina (Kaunas). 2022 Nov 21;58(11):1694. doi: 10.3390/medicina58111694.

Piperaquine-Induced QTc Prolongation Decreases With Repeated Monthly Dihydroartemisinin-Piperaquine Dosing in Pregnant Ugandan Women.

Clin Infect Dis. 2022 Aug 31;75(3):406-415. doi: 10.1093/cid/ciab965.

Arrhythmic risk during pregnancy and postpartum in patients with long QT syndrome.

Herzschrittmacherther Elektrophysiol. 2021 Jun;32(2):180-185. doi: 10.1007/s00399-021-00757-4. Epub 2021 Mar 29.

Sexual Dimorphisms, Anti-Hormonal Therapy and Cardiac Arrhythmias.

Int J Mol Sci. 2021 Feb 2;22(3):1464. doi: 10.3390/ijms22031464.

Randomized Controlled Trial of the Electrocardiographic Effects of Four Antimalarials for Pregnant Women with Uncomplicated Malaria on the Thailand-Myanmar Border.

Antimicrob Agents Chemother. 2021 Mar 18;65(4). doi: 10.1128/AAC.02473-20.

Progesterone Metabolites Inhibit the Human Ether-a-go-go-Related Gene and Predict QT Interval Length.

J Clin Pharmacol. 2020 May;60(5):648-659. doi: 10.1002/jcph.1563. Epub 2019 Dec 12.

本文引用的文献

Estradiol regulates human QT-interval: acceleration of cardiac repolarization by enhanced KCNH2 membrane trafficking.

Eur Heart J. 2016 Feb 14;37(7):640-50. doi: 10.1093/eurheartj/ehv371. Epub 2015 Aug 12.

How do sex hormones modify arrhythmogenesis in long QT syndrome? Sex hormone effects on arrhythmogenic substrate and triggered activity.

Heart Rhythm. 2014 Nov;11(11):2107-15. doi: 10.1016/j.hrthm.2014.06.023. Epub 2014 Jun 19.

Estradiol promotes sudden cardiac death in transgenic long QT type 2 rabbits while progesterone is protective.

Heart Rhythm. 2012 May;9(5):823-32. doi: 10.1016/j.hrthm.2012.01.009. Epub 2012 Jan 11.

KCNE1 D85N polymorphism--a sex-specific modifier in type 1 long QT syndrome?

BMC Med Genet. 2011 Jan 18;12:11. doi: 10.1186/1471-2350-12-11.

Non-genomic regulation of cardiac ion channels by sex hormones.

Cardiovasc Hematol Disord Drug Targets. 2008 Dec;8(4):245-51. doi: 10.2174/187152908786786160.

Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome.

J Clin Invest. 2008 Jun;118(6):2246-59. doi: 10.1172/JCI33578.

Long QT syndrome and pregnancy.

J Am Coll Cardiol. 2007 Mar 13;49(10):1092-8. doi: 10.1016/j.jacc.2006.09.054. Epub 2007 Feb 27.

Long QT syndrome in adults.

J Am Coll Cardiol. 2007 Jan 23;49(3):329-37. doi: 10.1016/j.jacc.2006.08.057. Epub 2007 Jan 4.

Estrogen and progestin use and the QT interval in postmenopausal women.

Ann Noninvasive Electrocardiol. 2004 Oct;9(4):366-74. doi: 10.1111/j.1542-474X.2004.94580.x.

Systemic levels of plasma progesterone during pregnancy in women and monkeys.

Endocrinology. 1951 Aug;49(2):218-24. doi: 10.1210/endo-49-2-218.

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Normalization of QT interval duration in a long QT syndrome patient during pregnancy and the postpartum period due to sex hormone effects on cardiac repolarization.

作者信息

Odening Katja E, Koren Gideon, Kirk Malcolm

机构信息

Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island.

Heart Center University of Freiburg, Department of Cardiology and Angiology I, Freiburg, Germany.

出版信息

HeartRhythm Case Rep. 2016 Mar 2;2(3):223-227. doi: 10.1016/j.hrcr.2015.12.012. eCollection 2016 May.

DOI:10.1016/j.hrcr.2015.12.012

PMID:28491674

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5419752/

Abstract

摘要

相似文献

Normalization of QT interval duration in a long QT syndrome patient during pregnancy and the postpartum period due to sex hormone effects on cardiac repolarization.

HeartRhythm Case Rep. 2016 Mar 2;2(3):223-227. doi: 10.1016/j.hrcr.2015.12.012. eCollection 2016 May.

Influence of Pregnancy in Patients With Congenital Long QT Syndrome.

Cardiol Rev. 2017 Jul/Aug;25(4):197-201. doi: 10.1097/CRD.0000000000000108.

Influence of pregnancy on the risk for cardiac events in patients with hereditary long QT syndrome. LQTS Investigators.

Circulation. 1998 Feb 10;97(5):451-6. doi: 10.1161/01.cir.97.5.451.

Sex differences in ventricular repolarization: from cardiac electrophysiology to Torsades de Pointes.

Fundam Clin Pharmacol. 2004 Apr;18(2):139-51. doi: 10.1111/j.1472-8206.2004.00230.x.

Non-genomic action of sex steroid hormones and cardiac repolarization.

Biol Pharm Bull. 2013;36(1):8-12. doi: 10.1248/bpb.b212021.

Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart.

Circulation. 1996 Sep 15;94(6):1471-4. doi: 10.1161/01.cir.94.6.1471.

Sex hormonal regulation of cardiac ion channels in drug-induced QT syndromes.

Pharmacol Ther. 2016 Dec;168:23-28. doi: 10.1016/j.pharmthera.2016.09.004. Epub 2016 Sep 4.

Gender and the relationship between ventricular repolarization and cardiac cycle length during 24-h Holter recordings.

Eur Heart J. 1997 Jun;18(6):1000-6. doi: 10.1093/oxfordjournals.eurheartj.a015357.

Electro-mechanical dysfunction in long QT syndrome: Role for arrhythmogenic risk prediction and modulation by sex and sex hormones.

Prog Biophys Mol Biol. 2016 Jan;120(1-3):255-69. doi: 10.1016/j.pbiomolbio.2015.12.010. Epub 2015 Dec 21.

Invited commentary: sex-steroid hormones and QT-interval duration.

Am J Epidemiol. 2011 Aug 15;174(4):412-5. doi: 10.1093/aje/kwr170. Epub 2011 Jul 18.

引用本文的文献

Long QT Interval Syndrome and Female Sex-Review and Case Report.

Reports (MDPI). 2025 Mar 17;8(1):32. doi: 10.3390/reports8010032.

Long QT Syndrome Management during and after Pregnancy.

Medicina (Kaunas). 2022 Nov 21;58(11):1694. doi: 10.3390/medicina58111694.

Piperaquine-Induced QTc Prolongation Decreases With Repeated Monthly Dihydroartemisinin-Piperaquine Dosing in Pregnant Ugandan Women.

Clin Infect Dis. 2022 Aug 31;75(3):406-415. doi: 10.1093/cid/ciab965.

Arrhythmic risk during pregnancy and postpartum in patients with long QT syndrome.

Herzschrittmacherther Elektrophysiol. 2021 Jun;32(2):180-185. doi: 10.1007/s00399-021-00757-4. Epub 2021 Mar 29.

Sexual Dimorphisms, Anti-Hormonal Therapy and Cardiac Arrhythmias.

Int J Mol Sci. 2021 Feb 2;22(3):1464. doi: 10.3390/ijms22031464.

Randomized Controlled Trial of the Electrocardiographic Effects of Four Antimalarials for Pregnant Women with Uncomplicated Malaria on the Thailand-Myanmar Border.

Antimicrob Agents Chemother. 2021 Mar 18;65(4). doi: 10.1128/AAC.02473-20.

Progesterone Metabolites Inhibit the Human Ether-a-go-go-Related Gene and Predict QT Interval Length.

J Clin Pharmacol. 2020 May;60(5):648-659. doi: 10.1002/jcph.1563. Epub 2019 Dec 12.

本文引用的文献

Estradiol regulates human QT-interval: acceleration of cardiac repolarization by enhanced KCNH2 membrane trafficking.

Eur Heart J. 2016 Feb 14;37(7):640-50. doi: 10.1093/eurheartj/ehv371. Epub 2015 Aug 12.

How do sex hormones modify arrhythmogenesis in long QT syndrome? Sex hormone effects on arrhythmogenic substrate and triggered activity.

Heart Rhythm. 2014 Nov;11(11):2107-15. doi: 10.1016/j.hrthm.2014.06.023. Epub 2014 Jun 19.

Estradiol promotes sudden cardiac death in transgenic long QT type 2 rabbits while progesterone is protective.

Heart Rhythm. 2012 May;9(5):823-32. doi: 10.1016/j.hrthm.2012.01.009. Epub 2012 Jan 11.

KCNE1 D85N polymorphism--a sex-specific modifier in type 1 long QT syndrome?

BMC Med Genet. 2011 Jan 18;12:11. doi: 10.1186/1471-2350-12-11.

Non-genomic regulation of cardiac ion channels by sex hormones.

Cardiovasc Hematol Disord Drug Targets. 2008 Dec;8(4):245-51. doi: 10.2174/187152908786786160.

Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome.

J Clin Invest. 2008 Jun;118(6):2246-59. doi: 10.1172/JCI33578.

Long QT syndrome and pregnancy.

J Am Coll Cardiol. 2007 Mar 13;49(10):1092-8. doi: 10.1016/j.jacc.2006.09.054. Epub 2007 Feb 27.

Long QT syndrome in adults.

J Am Coll Cardiol. 2007 Jan 23;49(3):329-37. doi: 10.1016/j.jacc.2006.08.057. Epub 2007 Jan 4.

Estrogen and progestin use and the QT interval in postmenopausal women.

Ann Noninvasive Electrocardiol. 2004 Oct;9(4):366-74. doi: 10.1111/j.1542-474X.2004.94580.x.

Systemic levels of plasma progesterone during pregnancy in women and monkeys.

Endocrinology. 1951 Aug;49(2):218-24. doi: 10.1210/endo-49-2-218.

Normalization of QT interval duration in a long QT syndrome patient during pregnancy and the postpartum period due to sex hormone effects on cardiac repolarization.

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Normalization of QT interval duration in a long QT syndrome patient during pregnancy and the postpartum period due to sex hormone effects on cardiac repolarization.

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