Kleyman T R, Cragoe E J
Department of Medicine, Columbia University, New York.
Semin Nephrol. 1988 Sep;8(3):242-8.
Amiloride induces a mild natriuresis as well as antikaliuresis. These changes in salt excretion are due to direct inhibition of the sodium channel in the apical plasma membrane of the distal nephron. Amiloride does not exert any direct or indirect inhibitory effect on apical potassium channels. The antikaliuretic effect is most likely a result of hyperpolarization of the apical plasma membrane and decrease in the electrochemical driving force for potassium movement across the apical membrane into the urinary space.
氨氯吡咪可引起轻度利钠作用及抗利尿钾作用。这些盐排泄的变化是由于直接抑制了远端肾单位顶端质膜中的钠通道。氨氯吡咪对顶端钾通道没有任何直接或间接的抑制作用。抗利尿钾作用很可能是顶端质膜超极化以及钾离子跨顶端膜进入尿液间隙的电化学驱动力降低的结果。
