Department of Ophthalmology, Saint Louis University, Saint Louis, MO, USA.
J Immunol Res. 2017;2017:7261980. doi: 10.1155/2017/7261980. Epub 2017 Apr 9.
Herpes simplex keratitis is a disease of the cornea caused by HSV-1. It is a leading cause of corneal blindness in the world. Underlying molecular mechanism is still unknown, but experimental models have helped give a better understanding of the underlying molecular pathology. Cytokines and chemokines are small proteins released by cells that play an important proinflammatory or anti-inflammatory role in modulating the disease process. Cytokines such as IL-17, IL-6, IL-1, and IFN- and chemokines such as MIP-2, MCP-1, MIP-1, and MIP-1 have proinflammatory role in the destruction caused by HSV including neutrophil infiltration and corneal inflammation, and other chemokines and cytokines such as IL-10 and CCL3 can have a protective role. Most of the damage results from neutrophil infiltration and neovascularization. While many more studies are needed to better understand the role of these molecules in both experimental models and human corneas, current studies indicate that these molecules hold potential to be targets of future therapy.
单纯疱疹性角膜炎是由单纯疱疹病毒 1 引起的角膜疾病。它是世界上导致角膜盲的主要原因。其潜在的分子机制尚不清楚，但实验模型有助于更好地理解潜在的分子病理学。细胞因子和趋化因子是细胞释放的小蛋白，在调节疾病过程中发挥重要的促炎或抗炎作用。细胞因子如 IL-17、IL-6、IL-1 和 IFN，以及趋化因子如 MIP-2、MCP-1、MIP-1 和 MIP-1 在 HSV 引起的破坏中具有促炎作用，包括中性粒细胞浸润和角膜炎症，而其他趋化因子和细胞因子如 IL-10 和 CCL3 可以发挥保护作用。大多数损伤是由中性粒细胞浸润和新生血管形成引起的。虽然还需要更多的研究来更好地了解这些分子在实验模型和人角膜中的作用，但目前的研究表明，这些分子有可能成为未来治疗的靶点。
