黄褐斑的激光与光疗法综述
A review of laser and light therapy in melasma.
作者信息
Trivedi M K, Yang F C, Cho B K
机构信息
University of Michigan Medical School, Ann Arbor, Michigan.
Department of Dermatology, University of California San Francisco, San Francisco, California.
出版信息
Int J Womens Dermatol. 2017 Mar 21;3(1):11-20. doi: 10.1016/j.ijwd.2017.01.004. eCollection 2017 Mar.
Melasma is a dysregulation of the homeostatic mechanisms that control skin pigmentation and excess pigment is produced. Traditional treatment approaches with topical medications and chemical peels are commonly used but due to the refractory and recurrent nature of melasma, patients often seek alternative treatment strategies such as laser and light therapy. Several types of laser and light therapy have been studied in the treatment of melasma. Intense pulsed light, low fluence Q-switched lasers, and non-ablative fractionated lasers are the most common lasers and light treatments that are currently performed. They all appear effective but there is a high level of recurrence with time and some techniques are associated with an increased risk for postinflammatory hyper- or hypopigmentation. The number and frequency of treatments varies by device type but overall, Q-switched lasers require the greatest number of treatment applications to see a benefit. Vascular-specific lasers do not appear to be effective for the treatment of melasma. Ablative fractionated lasers should be used with caution because they have a very high risk for postinflammatory hypo- and hyperpigmentation. The use of nonablative fractionated laser treatments compared with other laser and light options may result in slightly longer remission intervals. Picosecond lasers, fractional radiofrequency, and laser-assisted drug delivery are promising future approaches to treat melasma. The goal of this review is to summarize the efficacy and safety of the most commonly used laser and light therapies to treat melasma, briefly present future laser-based treatment options for patients with melasma, and provide recommendations for treatment on the basis of the reviewed information.
黄褐斑是控制皮肤色素沉着的稳态机制失调,从而产生过多色素。常用局部用药和化学剥脱等传统治疗方法,但由于黄褐斑具有难治性和复发性,患者常寻求激光和光疗等替代治疗策略。已有多种类型的激光和光疗用于黄褐斑的治疗。强脉冲光、低能量调Q激光和非剥脱性分次激光是目前最常用的激光和光治疗方法。它们似乎都有效,但随着时间推移复发率较高,且一些技术会增加炎症后色素沉着过度或色素减退的风险。治疗的次数和频率因设备类型而异,但总体而言,调Q激光需要最多的治疗次数才能见到效果。血管特异性激光似乎对黄褐斑治疗无效。剥脱性分次激光应谨慎使用,因为其炎症后色素减退和色素沉着过度的风险非常高。与其他激光和光疗方法相比,使用非剥脱性分次激光治疗可能会使缓解期稍长。皮秒激光、射频分次治疗和激光辅助药物递送是未来治疗黄褐斑的有前景的方法。本综述的目的是总结治疗黄褐斑最常用的激光和光疗的疗效和安全性,简要介绍黄褐斑患者未来基于激光的治疗选择,并根据所审查的信息提供治疗建议。