Division of Dermatology, Department of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Harvard Medical School, Wellman Centre for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts.
Lasers Surg Med. 2021 Oct;53(8):1032-1042. doi: 10.1002/lsm.23382. Epub 2021 Feb 5.
Facial melasma is a disfiguring pigmentation and occurs frequently with aging skin. Topical treatment alone was often suboptimal. A recent study showed that fractional picosecond laser has promising result in benign pigmentary lesions. This study aims to investigate the efficacy and safety of 1064 nm picosecond laser in treatment of facial melasma and skin rejuvenation in Asian skin.
STUDY DESIGN/MATERIALS AND METHODS: Patients of Asian descent seeking treatment for facial melasma and skin rejuvenation were screened and recruited. Each patient received up to nine laser treatments at 4-6 weeks intervals with a fractionated nonablative 1064 nm picosecond laser. Baseline and posttreatment modified Melasma Area Severity Index (mMASI) and Global Aesthetic Improvement Scale (IGAS) were assessed by blinded investigators based on the clinical photographs. Subject overall satisfaction was assessed by the questionnaires after treatment. All adverse events were documented.
Twenty patients were recruited with a median age of 52.7 ± 8.2 years. Three subjects had Fitzpatrick skin type III and 17 had skin type IV. All subjects received nine laser sessions. Over 70% of patients were satisfied with the treatment outcomes. There was a statistically significant improvement in mMASI which reduced from 10.8 at baseline to 2.7 and 3.6 at 6 and 12 weeks post-treatment, respectively (both P < 0.01). For skin rejuvenation, 70% reported at least a moderate improvement at 6 weeks of post-treatment. No major side-effect was reported. Erythema was the most frequent transient response, while some reported edema (1.1%). Both resolved spontaneously. None reported hypo- or hyperpigmentation after treatment. The overall mean pain scare (VAS) was 1.92.
Fractionated non-ablative 1064 nm picosecond laser was effective in treatment of melasma and skin rejuvenation. It was also safe and well tolerated. Importantly, there was no hypo or hyperpigmentation reported. Lasers Surg. Med. 00:00-00, 2021. © 2021 Wiley Periodicals LLC.
面部黄褐斑是一种影响容貌的色素沉着，常随衰老的皮肤而出现。单独的局部治疗往往效果不佳。最近的一项研究表明，皮秒激光 Fractional 在良性色素病变方面有很好的效果。本研究旨在探讨 1064nm 皮秒激光治疗亚洲人面部黄褐斑和皮肤年轻化的疗效和安全性。
研究设计/材料和方法：筛选并招募了寻求面部黄褐斑和皮肤年轻化治疗的亚洲患者。每位患者在 4-6 周的间隔内接受多达 9 次激光治疗，使用非剥脱性 1064nm 皮秒激光进行分割。根据临床照片，由盲法研究者评估治疗前后改良黄褐斑面积严重程度指数（mMASI）和整体美学改善量表（IGAS）。治疗后通过问卷调查评估患者的整体满意度。记录所有不良反应。
共招募了 20 名年龄中位数为 52.7±8.2 岁的患者。3 名患者为 Fitzpatrick 皮肤类型 III，17 名患者为皮肤类型 IV。所有患者均接受了 9 次激光治疗。超过 70%的患者对治疗结果满意。mMASI 有统计学显著改善，从基线的 10.8 分别降低至治疗后 6 周和 12 周的 2.7 和 3.6（均 P<0.01）。在皮肤年轻化方面，70%的患者在治疗后 6 周报告至少有中度改善。未报告主要不良反应。红斑是最常见的短暂反应，有些患者报告水肿（1.1%）。两者均自发消退。治疗后均无色素减退或色素沉着。总体平均疼痛评分（VAS）为 1.92。
非剥脱性 1064nm 皮秒激光治疗黄褐斑和皮肤年轻化有效且安全耐受。重要的是，未报告色素减退或色素沉着。激光外科医学 00:00-00,2021. © 2021 Wiley Periodicals LLC.
