Kyler J R, Krause S E, Mallory S B, Johnston Y E
Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock.
South Med J. 1988 Dec;81(12):1583-6. doi: 10.1097/00007611-198812000-00030.
We have described two children with multiple cutaneous granular cell tumors (GCT) and have reviewed the literature. Multiple tumors of the skin are relatively rare, especially in children, with only 18 pediatric cases previously reported. Surgical excision of rapidly growing or symptomatic lesions is the treatment of choice. In these two children with multiple GCT, three lesions were excised. Specific stains for enolase and S-100 protein clearly demarcated tumor margins after surgical excision. Despite intensive investigation, the histogenesis of this tumor is still in dispute. The most tenable theory at this time is that these tumors are derived either directly from Schwann cells or from undifferentiated cells developing neural characteristics.
我们描述了两名患有多发性皮肤颗粒细胞瘤（GCT）的儿童，并对文献进行了回顾。皮肤多发性肿瘤相对罕见，尤其是在儿童中，此前仅有18例儿科病例报道。手术切除快速生长或有症状的病变是首选治疗方法。在这两名患有多发性GCT的儿童中，切除了三个病变。烯醇化酶和S-100蛋白的特异性染色在手术切除后清晰地界定了肿瘤边缘。尽管进行了深入研究，但该肿瘤的组织发生仍存在争议。目前最合理的理论是，这些肿瘤要么直接源自施万细胞，要么源自具有神经特征的未分化细胞。
