Rifkin R H, Blocker S H, Palmer J O, Ternberg J L
Arch Surg. 1986 Aug;121(8):945-7. doi: 10.1001/archsurg.1986.01400080091017.
A 23-year-old black woman and her 6-year-old son, both with multiple granular cell tumors, are described herein. The mother and son both presented as children with multiple granular cell tumors. This is the first reported case of multiple lesions arising in childhood in successive generations. Only two other case studies of familial granular cell tumors have been reported, but in neither of these cases did multiple tumors present initially in both family members during childhood. A preponderance of multicentric lesions is reported in blacks. The tumors recurred locally in some of the sites where there were inadequate surgical margins, emphasizing the need for complete excision.
本文描述了一名23岁的黑人女性及其6岁儿子，二人均患有多发性颗粒细胞瘤。母亲和儿子均在儿童期就出现了多发性颗粒细胞瘤。这是首次报道的连续两代人在儿童期出现多发性病变的病例。此前仅报道过另外两例家族性颗粒细胞瘤的病例研究，但在这两例中，均没有家庭成员在儿童期最初就出现多个肿瘤。据报道，黑人中多中心病变更为常见。在一些手术切缘不充分的部位，肿瘤出现了局部复发，这凸显了完整切除的必要性。
