Williams P M, Williamson K A, Emerson S U
Department of Microbiology, University of Virginia School of Medicine, Charlottesville 22908.
Virology. 1988 Dec;167(2):342-8.
Three monoclonal antibodies directed against the NS protein of vesicular stomatitis virus inhibited homotypic in vitro transcription reactions. One antibody inhibited transcription only moderately while the other two antibodies inhibited total transcription by 90% or greater compared to control reactions. One antibody decreased the synthesis of all transcripts examined, the second antibody virtually abolished the synthesis of all transcripts, and the third antibody prevented mRNA synthesis but not leader RNA synthesis.
三种针对水疱性口炎病毒NS蛋白的单克隆抗体抑制了同型体外转录反应。一种抗体仅适度抑制转录，而另外两种抗体与对照反应相比，抑制总转录达90%或更高。一种抗体减少了所有检测转录本的合成，第二种抗体几乎完全消除了所有转录本的合成，第三种抗体阻止了mRNA的合成，但不影响前导RNA的合成。
