Stöckmann F, Creutzfeldt W
Abt. Gastroenterologie und Endokrinologie, Medizinische Univ.-Klinik Göttingen.
Z Gastroenterol. 1988 Oct;26(10):665-75.
Somatostatin, a 14 amino acid peptide hormone, is a potent inhibitor for secretion of gastrointestinal hormones from endocrine cells. The clinical use of somatostatin for treatment of endocrine gastrointestinal tumours was limited due to its short half-life (2-3 min). Octreotide (Sandostatin), a long-acting somatostatin analogue, has been developed for subcutaneous use with an elimination half-life of about 45 min. This offers a new way of long-term treatment for patients with endocrine gastrointestinal tumours. The effect of octreotide in various forms of these diseases and its importance for the possible inhibition of tumour growth are described.
生长抑素是一种由14个氨基酸组成的肽类激素，是内分泌细胞分泌胃肠激素的强效抑制剂。由于其半衰期较短（2 - 3分钟），生长抑素在治疗内分泌性胃肠肿瘤方面的临床应用受到限制。奥曲肽（善宁）是一种长效生长抑素类似物，已被开发用于皮下注射，消除半衰期约为45分钟。这为内分泌性胃肠肿瘤患者提供了一种新的长期治疗方法。本文描述了奥曲肽在这些疾病的各种形式中的作用及其对可能抑制肿瘤生长的重要性。
